Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics
Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics
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具有独特光学和磁功能的可降解二硫化钒纳米结构，用于癌症治疗学。
DOI：
10.1002/anie.201707128
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发表时间：
2017-10-09
影响因子：
16.6
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Chen, Yuyan;Cheng, Liang;Liu, Zhuang
多功能可生物降解的无机纳米治疗诊断剂是纳米医学领域的研究热点。在脂质修饰后，VS 2纳米片可以转化为封装在聚乙二醇（PEG）修饰的脂质胶束内的超小VS 2纳米点。由于VS 2的顺磁性、高近红外（NIR）吸收和无螯合剂的99 mTc 4+标记，这种VS2 @脂质-PEG纳米颗粒可用于T1加权磁共振（MR）、光声（PA）和单光子发射计算机断层扫描（SPECT）三模式成像引导的肿瘤光热消融。重要的是，沿着VS 2的逐渐降解，我们的VS2 @脂质-PEG纳米颗粒表现出有效的身体排泄而没有明显的毒性。VS 2纳米结构具有高度集成的功能和可生物降解的行为，这意味着它们在癌症治疗诊断中的应用前景广阔。
Multifunctional biodegradable inorganic theranostic nano-agents are of great interest to the field of nanomedicine. Upon lipid modification, VS2 nanosheets could be converted into ultra-small VS2 nanodots encapsulated inside polyethylene glycol (PEG) modified lipid micelles. Owing to paramagnetism, high near-infrared (NIR) absorbance, and chelator-free 99m Tc4+ labeling of VS2 , such VS2 @lipid-PEG nanoparticles could be used for T1-weighted magnetic resonance (MR), photoacoustic (PA),and single photon emission computed tomography (SPECT) tri-modal imaging guided photothermal ablation of tumors. Importantly, along with the gradual degradation of VS2 , our VS2 @lipid-PEG nanoparticles exhibit effective body excretion without appreciable toxicity. The unique advantages of VS2 nanostructures with highly integrated functionalities and biodegradable behaviors mean they are promising for applications in cancer theranostics.