Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation
Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation
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DOI：
10.1016/j.arabjc.2013.12.003
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发表时间：
2015-01-01
影响因子：
6
通讯作者：
Eldin, Mohamed S. Mohy
中科院分区：
文献类型：
--
作者：
Kamoun, Elbadawy A.;Kenawy, El-Refaie S.;Eldin, Mohamed S. Mohy
使用冻融方法开发了含有作为局部抗生素的氨比西林钠的PVA-海藻酸钠（SA）水凝胶膜，用于伤口敷料应用。将海藻酸钠水溶液与聚乙烯醇按一定比例混合，采用冻融法进行物理交联，代替传统的化学交联，避免了化学试剂和交联剂的危险性。测定了PVA-SA膜的物理化学性质，如凝胶分数和吸水率。增加SA含量与PVA降低PVA-SA膜的凝胶分数，弹性，和断裂伸长率。然而，它导致的溶胀度，蛋白质吸附，和膜表面粗糙度的增加。PVA膜中SA含量高对水凝胶膜的表面形态结构有明显影响。孔径和孔面积分布已观察到与添加高浓度的SA。然而，高SA含量对氨苄青霉素的释放没有显著影响。PVA-SA膜的水解降解随SA含量的增加而显著增加。此外，在PVA中加入SA后，对革兰氏阳性菌和阴性菌的溶血（%）和体外抑制（%）都有显著影响，表明血液相容性得到改善。因此，含有氨苄青霉素的PVA-SA水凝胶膜基伤口敷料系统可以是伤口护理中的良好聚合物膜候选物。(C)2013年沙特国王大学。Elsevier B. V.制作和主持。保留所有权利。
PVA-sodium alginate (SA) hydrogel membranes containing sodium ampicillin as a topical antibiotic were developed using the freeze-thawing method for wound dressing application. Aqueous solution of sodium alginate has been blended in a certain ratio with PVA, followed by the crosslinking method has been conducted by freeze-thawing method as physical crosslinking instead of the use of traditional chemical crosslinking to avoid riskiness of chemical reagents and crosslinkers. The physicochemical properties of PVA-SA membranes e.g. gel fraction and water uptake % have been performed. Increased SA content with PVA decreased gel fraction, elasticity, and elongation to break of PVA-SA membranes. However, it resulted in an increase in swelling degree, protein adsorption, and roughness of membrane surface. High SA content in PVA membranes had apparently an impact on surface morphology structure of hydrogel membranes. Pore size and pore area distribution have been observed with addition of high SA concentration. However, high SA content had an insignificant effect on the release of ampicillin. The hydrolytic degradation of PVA-SA membranes has prominently increased with increasing SA content. Furthermore, hemolysis (%) and in vitro inhibition (%) for both Gram positive and negative bacteria have been sharply affected by addition of SA into PVA, indicating the improved blood hemocompatibility. Thus, PVA-SA hydrogel membrane based wound dressing system containing ampicillin could be a good polymeric membrane candidate in wound care. (C) 2013 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.