REMOVAL OF NEUROBLASTOMA CELLS FROM BONE MARROW WITH MONOCLONAL ANTIBODIES CONJUGATED TO MAGNETIC MICROSPHERES
REMOVAL OF NEUROBLASTOMA CELLS FROM BONE MARROW WITH MONOCLONAL ANTIBODIES CONJUGATED TO MAGNETIC MICROSPHERES
复制标题
使用与磁性微球缀合的单克隆抗体从骨髓中去除神经母细胞瘤细胞
DOI：
10.1016/s0140-6736(84)90004-7
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
J. Kemshead
中科院分区：
文献类型：
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作者：
J. Treleaven;J. Ugelstad;T. Philip;F. Gibson;A. Rembaum;G. Caine;J. Kemshead
与含有磁铁矿的聚苯乙烯微球结合的单克隆抗体已被用于从骨髓中去除肿瘤细胞以进行自体移植。小磁珠可以靶向肿瘤细胞的表面，使其具有磁性。使用钐钴永磁体的流动系统可以快速有效地从骨髓中去除“磁性”肿瘤细胞。该系统被设计用于任何类型的肿瘤细胞，因此通过改变单克隆抗体的面板，它可以用于“清洁”许多不同恶性肿瘤的骨髓。
Monoclonal anibodies bound to polystyrene microspheres containing magnetite have been used to remove tumour cells from bone marrow destined for autologous transplantation. The small magnetic beads can be targeted to the surface of tumour cells to render these magnetic. A flow system using permanent samarium cobalt magnets effects the rapid and efficient removal of "magnetic" tumour cells from bone marrow. The system is designed to be used with any type of tumour cell, so that by changing panels of monoclonal antibody it can be used for "cleaning" the bone marrow in many different malignancies.