Incidence of cancer among patients with systemic sclerosis in Korea: results from a single centre
Incidence of cancer among patients with systemic sclerosis in Korea: results from a single centre
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DOI：
10.1080/03009740802642062
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发表时间：
2009-01-01
影响因子：
2.1
通讯作者：
Park, S-H
中科院分区：
文献类型：
--
作者：
Kang, K. Y.;Yim, H. W.;Park, S-H
目的：本研究的目的是确定韩国系统性硬化症 (SSc) 患者的癌症发病率是否有所增加。方法：研究对象包括 112 名在 1990 年至 2007 年间连续接受至少 6 个月评估的患者。我们回顾性审查了他们的病历，调查了癌症的发病率，并将其与韩国国家癌症中心数据库的数据进行了比较。结果：112 名患者中，9 名罹患癌症（4 名男性和 5 名男性）。女性）。诊断癌症的平均年龄为 56.4 岁，平均病程为 8.9 年。 SSc 患者的标准化发病率 (SIR) 为 4.2 [95% 置信区间 (CI) 2.3-6.1]，女性为 3.7 (95% CI 1.2-6.2)，男性为 6.4 (95% CI 1.6-11.2)。肺癌是最常见的癌症（n=4），其次是食道癌（n=1）、胃癌（n=1）、肝癌（n=1）、胰腺癌（n=1）和来源不明的鳞状细胞癌（n=1）。所有患肺癌的患者均为女性且来源为非小细胞癌。女性肺癌患者的SIR为23.0（95% CI 6.0-40.0）。四分之二的肺癌患者伴有间质性肺疾病（ILD）；所有人都不吸烟。患有或不患有癌症的 SSc 患者之间的治疗药物、自身抗体、吸烟和肺部受累情况没有显着差异。 结论：SSc 患者的癌症 SIR 显着高于一般人群，尤其是男性患者。肺癌是最常见的癌症。应对所有 SSc 患者进行主动监测以检测癌症。
Objective: The aim of this study was to determine whether the incidence of cancer has increased among patients with systemic sclerosis (SSc) in Korea.Methods: The study subjects consisted of 112 patients who had been consecutively evaluated for at least 6 months between 1990 and 2007. We retrospectively reviewed their medical records, investigated the incidence rate of cancer and compared it with that of the Korea National Cancer Centre database.Results: Nine out of 112 patients developed cancer (four males and five females). The average age at diagnosis of cancer was 56.4 years and the mean disease duration was 8.9 years. The standardized incidence ratio (SIR) for SSc patients was 4.2 [95% confidence interval (CI) 2.3-6.1], 3.7 for women (95% CI 1.2-6.2) and 6.4 for men (95% CI 1.6-11.2). Lung cancer was the most common cancer (n=4), followed by oesophagus (n=1), stomach (n=1), liver (n=1), pancreas (n=1), and squamous cell carcinoma of unknown origin (n=1). All patients who developed lung cancer were female and non-small cell carcinoma in origin. The SIR of lung cancer in female patients was 23.0 (95% CI 6.0-40.0). Two out of four lung cancer patients had concomitant interstitial lung disease (ILD); all were non-smokers. Treatment agents, autoantibodies, smoking, and lung involvement were not significantly different between SSc patients with or without cancer.Conclusion: The SIR of cancer was significantly higher in SSc patients, and especially in those who were male, than in the general population. Lung cancer was the most common cancer. Active surveillance for the detection of cancer should be performed in all SSc patients.