14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries
14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries
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DOI：
10.1161/01.hyp.0000153462.06604.5d
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发表时间：
2005-04-01
期刊：
影响因子：
8.3
通讯作者：
Campbell, WB
中科院分区：
文献类型：
--
作者：
Gauthier, KM;Edwards, EM;Campbell, WB
Bradykinin causes arterial relaxation and hyperpolarization, which is mediated by a transferable endothelium-derived hyperpolarizing factor ( EDHF). In coronary arteries, epoxyeicosatrienoic acids (EETs) are involved in the EDHF response. However, the role of EETs as transferable mediators of EDHF-dependent relaxation remains poorly defined. Two small bovine coronary arteries were cannulated and perfused in tandem in the presence of the nitric oxide synthase inhibitor, nitro-L-arginine (30 mu mol/L), and the cyclooxygenase inhibitor, indomethacin (10 mu mol/L). Luminal perfusate from donor arteries with intact endothelium perfused endothelium-denuded detector arteries. Detector arteries were constricted with U46619 and diameters were monitored. Bradykinin (10 nmol/L) added to detector arteries did not induce dilation (5 +/- 2%), whereas bradykinin addition to donor arteries dilated detector arteries by 26.5 +/- 7% (P
