Surface modification enhances interfacial bonding in PLLA/MgO bone scaffold
Surface modification enhances interfacial bonding in PLLA/MgO bone scaffold
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表面改性增强 PLLA/MgO 骨支架的界面结合
DOI：
10.1016/j.msec.2019.110486
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发表时间：
2020-03-01
影响因子：
7.9
通讯作者：
Tian, Zongjun
中科院分区：
文献类型：
--
作者：
Shuai, Cijun;Zan, Jun;Tian, Zongjun
聚合物基复合材料中纳米粒子界面结合不良，团聚现象严重，严重影响了复合材料的增强效果。本工作采用L-乳酸-苹果酸共聚物对氧化镁纳米颗粒进行表面改性，以改善L-乳酸选择性激光烧结支架的界面相容性。PLMA的亲水性末端带有羧基(来自苹果酸)和I-乳酸链。一方面，羧基能够与氧化镁纳米颗粒的羟基形成氢键。另一方面，含有羟基的L-乳酸链可以与聚乳酸的羧基发生反应。结果表明，该支架的抗压强度和弹性模量分别提高了47.1%和237.7%，这主要归因于聚乳酸与纳米氧化镁之间界面结合的增强以及刚性颗粒的增强。此外，该支架具有良好的亲水性和适宜的pH环境，有利于细胞的黏附、增殖和分化。提示该支架是一种有前途的骨修复材料。
The poor interfacial bonding and resultant agglomeration of nanoparticles in polymer-based composite severely deteriorated their reinforcement effect. In this work, MgO nanoparticles (MgO-NPs) were surface modified with Poly (L-lactic acid-co-malic acid) (PLMA) to improve the interfacial compatibility in Poly-l-lactic acid (PLLA) scaffold manufactured by selective laser sintering. PLMA possess a hydrophilic end with carboxyl group (comes from the malic acid) and an I-lactic acid chain. On one hand, the carboxyl group was able to form hydrogen bonding with the hydroxyl groups of MgO-NPs. On the other hand, the l-lactic acid chain containing the hydroxyl groups could react with the carboxyl group of PLLA. Results revealed that the scaffold exhibited significantly enhanced compressive strength and modulus by 47.1% and 237.7%, respectively, which could be ascribed to the enhanced interfacial bonding between PLLA and MgO-NPs, as well as the rigid particle reinforcement. In addition, the scaffold was favorable for cell adhesion, proliferation and differentiation, owing to the improved hydrophilic and suitable pH environment. It was suggested the scaffold was a promising material for bone repair application.