Physical activity and osteoporotic fracture risk in older women. Study of Osteoporotic Fractures Research Group.
Physical activity and osteoporotic fracture risk in older women. Study of Osteoporotic Fractures Research Group.
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DOI：
10.1097/00008483-199811000-00016
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发表时间：
1998
影响因子：
39.2
通讯作者：
E. Gregg;J. Cauley;D. Seeley;K. Ensrud;D. Bauer
中科院分区：
文献类型：
--
作者：
E. Gregg;J. Cauley;D. Seeley;K. Ensrud;D. Bauer
背景：体力活动与增加骨量和改善身体功能有关，因此可以降低骨质疏松性骨折的风险。目的确定高水平的体力活动是否与髋部、腕部和椎骨骨折的低发病率有关。设计前瞻性队列研究。在马里兰州的巴尔的摩、俄勒冈州的波特兰、明尼苏达州的明尼阿波利斯和宾夕法尼亚州的莫农加希拉谷设有四个临床中心。参与者9704名65岁或以上的非黑人女性。在基线时通过问卷调查评估身体活动。髋关节和腕关节骨折平均随访7.6年。在基线和平均3.7年后，通过使用X线摄影从形态计量学上确定椎骨骨折的发生率。结果：在调整年龄、饮食因素、基线时的福尔斯跌倒、功能和健康状况后，较高水平的休闲时间、体育活动和家务劳动以及每天坐着的时间较少与髋部骨折的相对风险显著降低相关。非常活跃的女性（第四和第五分位数）与最不活跃的女性（最低五分位数）相比，髋部骨折发生率降低了36%（相对风险，0.64 [95%CI，0.45 - 0.891），具有统计学意义。体力活动的强度也与骨折风险有关：与不活动的女性相比，中度至剧烈活动的女性髋部和椎骨骨折的风险分别降低了42%和33%。总的体力活动，每天做家务的时间，每天坐着的时间与手腕或脊椎骨折没有显著相关。结论：在社区老年妇女中，体力活动与髋部骨折风险降低相关，但与手腕或椎骨骨折无关。
BACKGROUND Physical activity has been related to enhanced bone mass and improved physical functioning and thus may reduce the risk for osteoporotic fracture. OBJECTIVE To determine whether higher levels of physical activity are related to lower incidence of hip, wrist, and vertebral fractures. DESIGN Prospective cohort study. SETTING Four clinical centers in Baltimore, Maryland; Portland, Oregon; Minneapolis, Minnesota; and the Monongahela Valley, Pennsylvania. PARTICIPANTS 9704 nonblack women 65 years of age or older. MEASUREMENTS Physical activity was assessed by questionnaire at baseline. Hip and wrist fractures were followed for an average of 7.6 years. The incidence of vertebral fracture was determined morphometrically by using radiography at baseline and an average of 3.7 years later. RESULTS Higher levels of leisure time, sport activity, and household chores and fewer hours of sitting daily were associated with a significantly reduced relative risk for hip fracture after adjustment for age, dietary factors, falls at baseline, and functional and health status. Very active women (fourth and fifth quintiles) had a statistically significant 36% reduction in hip fractures (relative risk, 0.64 [95% CI, 0.45 to 0.891) compared with the least active women (lowest quintile). The intensity of physical activity was also related to fracture risk: Moderately to vigorously active women had statistically significant reductions of 42% and 33% in risk for hip and vertebral fractures, respectively, compared with inactive women. Total physical activity, hours of household chores per day, and hours of sitting per day were not significantly associated with wrist or vertebral fractures. CONCLUSIONS Among older community-dwelling women, physical activity is associated with a reduced risk for hip fracture but not wrist or vertebral fracture.