Cerebral microbleeds and cognitive functioning in the PROSPER study
Cerebral microbleeds and cognitive functioning in the PROSPER study
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DOI：
10.1212/wnl.0b013e318232ab1d
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发表时间：
2011-10-01
期刊：
影响因子：
9.9
通讯作者：
van Buchem, M. A.
中科院分区：
文献类型：
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作者：
van Es, A. C. G. M.;van der Grond, J.;van Buchem, M. A.
目的：脑微出血(MBS)是脑部小血管疾病的重要指标，其患病率随年龄增长而增加。人们对住房抵押贷款证券化在人口老龄化中的功能后果知之甚少。在本研究中，我们调查了Prosper研究中MBS的存在和位置是否与认知有关。方法：对439名受试者记录MBS的数量和位置(皮质下、深部白质、基底节和幕下)。通过在线性混合模型中输入变量性别、年龄、白质高强度体积、梗死和MBS来计算患有和不患有MBS的受试者之间的认知表现差异。结果：在校正了性别、年龄、白质高强度体积和脑梗塞后，幕下MBS受试者在即刻图词学习测验、延迟图词学习和日常生活工具活动中的得分显著降低。结论：我们的数据表明，在血管风险增加的老年个体中，幕下MBS与认知功能丧失有关。神经病学(R)2011；77：1446-1452
Objectives: Cerebral microbleeds (MBs) are an important indicator of cerebral small-vessel disease, and their prevalence increases with increasing age. Little is known about the functional consequences of MBs in the aging population. In this study we investigated whether the presence and location of MBs are associated with cognition in the PROSPER study.Methods: For 439 subjects the number and location (cortico-subcortical, deep white matter, basal ganglia, and infratentorial) of the MBs was recorded. Difference in cognitive performance between subjects with and without MBs was calculated by entering the variables sex, age, white matter hyperintensity volume, infarction, and MBs in a linear mixed model. Differences in cognition between subjects with and without one or more MBs at different anatomic locations were assessed using the same model.Results: We found that after correction for sex, age, white matter hyperintensity volume, and infarction, subjects with infratentorial MBs had a significantly lower score on the Immediate Picture-Word Learning test, Delayed Picture-Word Learning, and Instrumental Activities of Daily Living.Conclusions: Our data demonstrate that in elderly individuals at increased vascular risk, infratentorial MBs are associated with loss in cognitive functioning. Neurology (R) 2011;77:1446-1452