Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI.
Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI.
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DOI：
10.1016/j.jacc.2020.09.546
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发表时间：
2020-11-17
影响因子：
24
通讯作者：
Dudek D
中科院分区：
文献类型：
--
作者：
De Luca G;Verdoia M;Cercek M;Jensen LO;Vavlukis M;Calmac L;Johnson T;Ferrer GR;Ganyukov V;Wojakowski W;Kinnaird T;van Birgelen C;Cottin Y;IJsselmuiden A;Tuccillo B;Versaci F;Royaards KJ;Berg JT;Laine M;Dirksen M;Siviglia M;Casella G;Kala P;Díez Gil JL;Banning A;Becerra V;De Simone C;Santucci A;Carrillo X;Scoccia A;Amoroso G;Lux A;Kovarnik T;Davlouros P;Mehilli J;Gabrielli G;Rios XF;Bakraceski N;Levesque S;Cirrincione G;Guiducci V;Kidawa M;Spedicato L;Marinucci L;Ludman P;Zilio F;Galasso G;Fabris E;Menichelli M;Garcia-Touchard A;Manzo S;Caiazzo G;Moreu J;Forés JS;Donazzan L;Vignali L;Teles R;Benit E;Agostoni P;Bosa Ojeda F;Lehtola H;Camacho-Freiere S;Kraaijeveld A;Antti Y;Boccalatte M;Deharo P;Martínez-Luengas IL;Scheller B;Alexopoulos D;Moreno R;Kedhi E;Uccello G;Faurie B;Gutierrez Barrios A;Di Uccio FS;Wilbert B;Smits P;Cortese G;Parodi G;Dudek D
2019冠状病毒病（COVID-19）大流行期间对传染病的恐惧可能会抑制ST段抬高型心肌梗死（STEMI）患者进入急诊系统，从而影响死亡率。ISACS-STEMI COVID-19登记研究旨在评估COVID-19大流行对接受直接经皮冠状动脉介入治疗（PPCI）的STEMI患者的治疗和结局的真实影响，并识别未能出现或延迟治疗的“高危”患者队列。该回顾性登记研究在欧洲大容量PPCI中心进行，并评估了2019年3月/4月和2020年接受PPPCI治疗的STEMI患者。主要结局是PPCI的发生率、延迟治疗和住院死亡率。在18个国家的77个中心，共有6，609例患者接受了PPCI。2020年，疫情期间，PPCI较2019年显著下降（发病率比：0. 811; 95%置信区间：0. 78 ~ 0. 84; p <0. 0001）。各中心之间的异质性与COVID-19导致的死亡发生率无关。在动脉高血压患者中观察到显著的相互作用，2020年的入院频率低于2019年。此外，大流行还与门到球囊和总缺血时间的显著增加有关，这可能是大流行期间死亡率较高的原因。COVID-19疫情对STEMI患者的治疗产生了重大影响，PPCI手术减少了19%，尤其是患有高血压的患者，治疗延迟时间更长，这可能导致疫情期间死亡率上升。（COVID-19大流行期间STEMI的初次血管成形术[ISACS-STEMI COVID-19]登记研究; NCT 04412655）。
The fear of contagion during the coronavirus disease-2019 (COVID-19) pandemic may have potentially refrained patients with ST-segment elevation myocardial infarction (STEMI) from accessing the emergency system, with subsequent impact on mortality. The ISACS-STEMI COVID-19 registry aims to estimate the true impact of the COVID-19 pandemic on the treatment and outcome of patients with STEMI treated by primary percutaneous coronary intervention (PPCI), with identification of “at-risk” patient cohorts for failure to present or delays to treatment. This retrospective registry was performed in European high-volume PPCI centers and assessed patients with STEMI treated with PPPCI in March/April 2019 and 2020. Main outcomes are the incidences of PPCI, delayed treatment, and in-hospital mortality. A total of 6,609 patients underwent PPCI in 77 centers, located in 18 countries. In 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio: 0.811; 95% confidence interval: 0.78 to 0.84; p < 0.0001). The heterogeneity among centers was not related to the incidence of death due to COVID-19. A significant interaction was observed for patients with arterial hypertension, who were less frequently admitted in 2020 than in 2019. Furthermore, the pandemic was associated with a significant increase in door-to-balloon and total ischemia times, which may have contributed to the higher mortality during the pandemic. The COVID-19 pandemic had significant impact on the treatment of patients with STEMI, with a 19% reduction in PPCI procedures, especially among patients suffering from hypertension, and a longer delay to treatment, which may have contributed to the increased mortality during the pandemic. (Primary Angioplasty for STEMI During COVID-19 Pandemic [ISACS-STEMI COVID-19] Registry; NCT04412655).
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影响因子：
3.3
作者：
Ibanez, Borja;James, Stefan;Widimsky, Petr
通讯作者：
Widimsky, Petr
影响因子：
39.3
作者：
De Rosa, Salvatore;Spaccarotella, Carmen;Indolfi, Ciro
通讯作者：
Indolfi, Ciro
DOI：
10.1111/jth.14817
发表时间：
2020-05
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
通讯作者：
--
影响因子：
37.8
作者：
De Luca, G;Suryapranata, H;Antman, EM
通讯作者：
Antman, EM
影响因子：
168.9
作者：
de Abajo, Francisco J.;Rodriguez-Martin, Sara;Rodriguez-Puyol, Diego
通讯作者：
Rodriguez-Puyol, Diego