A new dose-finding design for bivariate outcomes
A new dose-finding design for bivariate outcomes
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DOI：
10.1111/j.0006-341x.2003.00115.x
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发表时间：
2003-12-01
期刊：
影响因子：
1.9
通讯作者：
Ivanova, A
中科院分区：
文献类型：
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作者：
Ivanova, A
对于某些药物，毒性事件导致在观察到治疗反应之前提前终止治疗。也就是说，有三种可能的结果：毒性（治疗反应未知）、无毒性的治疗反应和无毒性的无反应。最佳剂量是使联合事件、反应和无毒性的概率最大化的剂量。最佳安全剂量是在毒性率低于最大耐受水平的剂量中，使反应概率最大化且无毒性的剂量。我们提出了一种新的序贯设计，以最大限度地增加受试者的数量分配在附近的最佳安全剂量的剂量探索试验有两个结果。
For some drugs, toxicity events lead to early termination of treatment before a therapeutic response is observed. That is, there are three possible outcomes: toxicity (therapeutic response unknown), therapeutic response without toxicity, and no response with no toxicity. The optimal dose is the dose that maximizes the probability of the joint event, response, and no toxicity. The optimal safe dose is the dose, from among the doses with toxicity rate less than the maximum tolerable level, that maximizes the probability of response and no toxicity. We present a new sequential design to maximize the number of subjects assigned in the neighborhood of the optimal safe dose in a dose-finding trial with two outcomes.