Liposarcoma of the head and neck: Analysis of 318 cases with comparison to non-head and neck sites
Liposarcoma of the head and neck: Analysis of 318 cases with comparison to non-head and neck sites
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DOI：
10.1002/hed.23311
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发表时间：
2014-03-01
影响因子：
2.9
通讯作者：
Lentsch, Eric J.
中科院分区：
文献类型：
--
作者：
Gerry, Daniel;Fox, Nyssa F.;Lentsch, Eric J.
研究背景：头颈部脂肪肉瘤少见。我们分析了大量的头颈部脂肪肉瘤，以确定头颈部独特的特征。方法使用监测、流行病学和最终结果（SEER）数据库，将318例头颈部脂肪肉瘤与9485例其他区域的脂肪肉瘤进行对比。结果头颈部脂肪肉瘤最常见于皮下（81.%），低度恶性（70.1%;P<0.001）和早期（P<0.001）。他们更可能接受单纯手术治疗，而传统的脂肪肉瘤更可能接受辅助放疗（p<0.001）。包括手术在内的治疗比单纯放射治疗的生存率更高（p= 0.008）。总的来说，头颈部脂肪肉瘤的疾病特异性生存率（DSS）和总生存率（OS）显著高于传统脂肪肉瘤（p< .001）。结论头颈部脂肪肉瘤通常是早期、低级别，淋巴结转移比传统脂肪肉瘤少。头颈部脂肪肉瘤的DSS和OS显著更高。© 2013 Wiley Periodicals，Inc.头颈部36：393-400，2014
BackgroundLiposarcomas are rare in the head and neck. We analyzed a large series of head and neck liposarcomas to determine features unique to the head and neck.MethodsThree hundred eighteen liposarcomas of the head and neck were contrasted with 9485 liposarcomas of other regions using the Surveillance, Epidemiology, and End Results (SEER) database.ResultsHead and neck liposarcomas were most commonly subcutaneous (81.%), low grade (70.1%;p< .001), and early stage (p< .001). They were more likely to be treated with surgery alone, whereas conventional liposarcomas were more likely to receive adjuvant radiation (p< .001). Treatment that included surgery had better survival than radiation therapy alone (p= .008). Overall, liposarcomas of the head and neck had significantly higher disease‐specific survival (DSS) and overall survival (OS) than conventional liposarcomas (p< .001).ConclusionLiposarcomas of the head and neck are usually early stage, low grade, and with fewer nodal metastases than conventional liposarcomas. DSS and OS were significantly greater for liposarcomas of the head and neck. © 2013 Wiley Periodicals, Inc. Head Neck36: 393–400, 2014