The intracellular fate of Salmonella depends on the recruitment of kinesin
The intracellular fate of Salmonella depends on the recruitment of kinesin
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DOI：
10.1126/science.1110225
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发表时间：
2005-05-20
期刊：
影响因子：
56.9
通讯作者：
Méresse, S
中科院分区：
文献类型：
--
作者：
Boucrot, E;Henry, T;Méresse, S
肠道沙门氏菌引起多种疾病，包括胃肠炎和伤寒。这种病原体的成功取决于其在宿主细胞内的膜结合区室中增殖的能力。我们发现，含沙门氏菌的液泡招募正末端定向运动驱动蛋白。细菌效应蛋白易位到宿主细胞的III型分泌系统拮抗调节这一事件。在这些效应子中，SifA靶向SKIP，SKIP是一种下调细菌上驱动蛋白募集的宿主蛋白。液泡，反过来，控制液泡膜动力学。
Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. The success of this pathogen depends on its capacity to proliferate within host cells in a membrane-bound compartment. We found that the Salmonella-containing vacuole recruited the plus-end-directed motor kinesin. Bacterial effector proteins translocated into the host cell by a type III secretion system antagonistically regulated this event. Among these effectors, SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial. vacuole and, in turn, controlled vacuolar membrane dynamics.