Flow-activated transport events along the nephron.
Flow-activated transport events along the nephron.
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沿肾单位的血流激活转运事件。
DOI：
10.1097/01.mnh.0000242180.46362.c4
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发表时间：
2006
影响因子：
3.2
通讯作者：
Wang,Tong
中科院分区：
文献类型：
--
作者：
Wang,Tong
流量调节的NHE 3活性是GTB的调节机制。它不依赖于神经元和全身激素的调节，但需要完整的肌动蛋白细胞骨架来传递由刷状缘微绒毛感知的改变的轴流信号。尚未回答的问题包括识别特定的信号转导机制和响应流的第二信使。TAL中Na+/2Cl-/K+协同转运蛋白是否是流量激活的，以及二价阳离子Ca 2+和Mg 2+的转运是否受流量调节尚不清楚。
Flow-modulated NHE3 activity is the regulatory mechanism for GTB. It is independent of neuron and systemic hormonal regulation, but requires the intact actin cytoskeleton to transmit the signal of altered axial flow sensed by brush-border microvilli. Unanswered questions include the identification of specific signaling transduction mechanisms and second messengers in response to flow. Whether the Na+/2Cl–/K+-cotransporter in TAL is flow-activated, and whether a divalent cation, Ca 2+ and Mg 2+ transport, can be regulated by flow is unknown.