Nodal expression and detection in cancer: experience and challenges.
Nodal expression and detection in cancer: experience and challenges.
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DOI：
10.1158/0008-5472.can-11-3419
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发表时间：
2012-04-15
期刊：
影响因子：
11.2
通讯作者：
Hendrix MJ
中科院分区：
文献类型：
--
作者：
Strizzi L;Hardy KM;Kirschmann DA;Ahrlund-Richter L;Hendrix MJ
NONAL是一种与转化生长因子β相关的胚胎形态原，在多种人类肿瘤中表达。如果不考虑与节点转录和蛋白质处理相关的问题，检测这些组织中的节点表达可能是具有挑战性的。在这里，我们讨论与Nodal表达和功能相关的某些特征，以及这些特征如何促进表达数据的获取和解释，有助于我们理解Nodal在人类癌症中的潜在作用。我们还讨论了Nodal如何作为癌症进展和治疗靶点的新生物标记物在临床上被利用。
Nodal is a TGF-beta related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function, and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.