A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface
A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface
复制标题
分级微/亚微织构3D打印Ti6Al4V表面与SLA表面成骨性能的对比研究
DOI：
10.1016/j.bioactmat.2019.12.008
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发表时间：
2020-03-01
影响因子：
18.9
通讯作者：
Lin, Kaili
中科院分区：
文献类型：
--
作者：
Zhang, Jinkai;Liu, Jiaqiang;Lin, Kaili
三维(3D)打印钛及其合金在生物医学植入材料领域具有广阔的应用前景，但原始表面的生物学性能有待提高。借鉴传统钛种植体的发展经验，构建层次化的混合拓扑面是今后的努力方向。由于原始3D打印的Ti6Al4V表面本质上具有微米级的特征，在本研究中，我们通过酸蚀在原始表面上引入亚微米级的凹坑，以获得层次化的微/亚微米纹理表面。在体内外评价了3D打印酸蚀(3DA)表面的特性和生物学性能，并与传统的喷砂、大颗粒、酸蚀(SLA)表面进行了比较。结果表明，骨髓间充质基质细胞(BMSCs)的黏附、增殖、成骨分化以及3DA表面的体内骨整合均有明显改善。然而，3DA表面的整体成骨性能不如常规SLA表面。
Three-dimensional (3D) printed titanium and its alloys have broad application prospect in the field of biomedical implant materials, although the biological performance of the original surface should be improved. Learning from the development experience of conventional titanium implants, to construct a hierarchical hybrid topological surface is the future direction of efforts. Since the original 3D-printed (3D hereafter) Ti6Al4V surface inherently has micron-scale features, in the present study, we introduced submicron-scale pits on the original surface by acid etching to obtain a hierarchical micro/submicro-textured surface. The characteristic and biological performance of the 3D-printed and acid-etched (3DA hereafter) surface were evaluated in vitro and in vivo, compared with the conventional sandblasted, large-grit, acid-etched (SLA hereafter) surface. Our results suggested the adhesion, proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells (BMSCs), as well as the in vivo osseointegration on 3DA surfaces were significantly improved. However, the overall osteogenic performance of the 3DA surface was not as good as the conventional SLA surface.