RAT-BRAIN SEROTONIN - BIOCHEMICAL AND FUNCTIONAL EVIDENCE FOR A SEX DIFFERENCE
RAT-BRAIN SEROTONIN - BIOCHEMICAL AND FUNCTIONAL EVIDENCE FOR A SEX DIFFERENCE
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DOI：
10.1007/bf01252033
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
CARLSSON, A
中科院分区：
文献类型：
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作者：
CARLSSON, M;SVENSSON, K;CARLSSON, A
比较雄性和雌性大鼠的脑5-羟色胺（5-HT）水平、合成能力、受体敏感性和中枢神经系统功能。雌性大鼠全脑5-HT和5-羟吲哚乙酸（5-HIAA）水平较高。单胺氧化酶抑制剂帕吉林单独和与5-羟色胺前体L-色氨酸组合治疗后，5-羟色胺的积累在女性比男性更大。在给予5-HT激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）后，两性的5-HT升高和5-HIAA降低的程度相同。所有药物治疗后的温度下降更大的女性，但“5-HT行为综合征”更明显的女性，只是在帕吉林加色氨酸后，8-OH-DPAT后的行为反应没有性别之间的差异。这些结果表明大脑5-HT神经元系统的性别差异。他们讨论了男性和女性之间的差异，在性行为，侵略和情感障碍。
Male and female rats were compared with respect to brain serotonin (5-HT) levels, synthetic capacity, receptor sensitivity, and CNS functions. Levels of whole brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) were higher in females. The accumulation of 5-HT after treatment with the monoamine oxidase inhibitor pargyline alone and in combination with the 5-HT precursor L-tryptophan was greater in females than in males. 5-HT increased and 5-HIAA decreased to the same extent in both sexes after administrtion of the 5-HT agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). The temperature fall after all drug treatments was greater in females, but the "5-HT behavioural syndrome" was more pronounced in females merely after pargyline plus tryptophan; the behavioural response after 8-OH-DPAT did not differ between the sexes. These results are indicative of sex differences in the brain 5-HT neuronal systems. They are discussed in relation to differences between males and females in sexual behaviour, aggression and affective disorders.