Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities
Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities
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DOI：
10.1021/ja102316a
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发表时间：
2010-06-23
影响因子：
15
通讯作者：
Thayumanavan, S.
中科院分区：
文献类型：
--
作者：
Ryu, Ja-Hyoung;Jiwpanich, Siriporn;Thayumanavan, S.
自组装系统的稳定性在血液循环中受到限制，因为组装形成所需的浓度。为了进行稳定的包封、靶向和触发释放的分子设计，我们开发了一种简单的合成方法，使用简单的链内/链间交联反应来合成高度稳定的聚合物纳米凝胶。我们展示了一种简单的、无乳液的制备生物相容性纳米凝胶的方法，这种方法提供了包封疏水客体分子和表面功能化的能力，具有靶向递送的潜力。我们表明，非共价封装的客体分子可以释放响应生物相关的刺激。
The stability of encapsulation in self-assembly systems is limited during blood circulation because of a requisite concentration for assembly formation. For deliberate molecular design for stable encapsulation, targeting, and triggered release, we have developed a facile synthetic method for highly stable, polymeric nanogels using a simple intra/interchain cross-linking reaction. We show a simple, emulsion-free method for the preparation of biocompatible nanogels that provides the ability to encapsulate hydrophobic guest molecules and surface functionalization which has potential for targeted delivery. We show that the noncovalently encapsulated guest molecules can be released in response to a biologically relevant stimulus.