Survival of AIDS patients according to type of AIDS-defining event
Survival of AIDS patients according to type of AIDS-defining event
复制标题
DOI：
10.1093/ije/26.2.400
复制
发表时间：
1997-04-01
影响因子：
7.7
通讯作者：
Phillips, AN
中科院分区：
文献类型：
--
作者：
Mocroft, AJ;Lundgren, JD;Phillips, AN
背景已知诊断为AIDS的患者的预后存在很大差异。在这项对来自17个欧洲中心的6578名AIDS患者的研究中，我们制定了AIDS定义疾病的排名，并确定该排名在调整潜在混杂变量后保持的程度。方法，计算每个AIDS定义事件的生存率，并使用Kaplan-Meier估计的中位生存率进行排名。采用考克斯比例风险模型，将每种疾病建模为时间依赖性协变量，以确定每次诊断后、校正潜在混杂因素前后的死亡风险。进行性多灶性白质脑病和恶性淋巴瘤的最初AIDS定义诊断后的中位生存期特别差（分别为2和5个月），而卡波西肉瘤和肺外结核的最初AIDS定义疾病后的中位生存期最长（分别为17和22个月）。原发性脑淋巴瘤患者的中位生存期短于外周淋巴瘤患者（中位生存期分别为1个月和4个月，P
Background. There are known to be wide differences in the prognosis of patients with a diagnosis of AIDS, In this study of 6578 patients with AIDS from 17 European centres, we develop a ranking of AIDS-defining illnesses, and determine how well this ranking holds alter adjustment for potential confounding variables,Methods, Survival from each AIDS-defining event was calculated and ranked using Kaplan-Meier estimation of median survival, Cox proportional hazards models with each disease modelled as a time dependant covariate were used to determine the risk of death after each diagnosis, before and after adjustment for potential confounders,Results. Median survival after an initial AIDS-defining diagnosis of progressive multifocal leukoencephalopathy and malignant lymphoma was particularly poor (2 and 5 months respectively), while the longest median survival occurred alter initial AIDS-defining illnesses of Kaposi's sarcoma and extrapulmonary tuberculosis (17 and 22 months respectively). Patients diagnosed with a primary brain lymphoma had shorter median survival times than patients with a peripheral lymphoma (median survival of 1 month and 4 months respectively, P