The Youden Index in the Generalized Receiver Operating Characteristic Curve Context
The Youden Index in the Generalized Receiver Operating Characteristic Curve Context
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DOI：
10.1515/ijb-2018-0060
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发表时间：
2019-05-01
影响因子：
1.2
通讯作者：
Carlos Pardo-Fernandez, Juan
中科院分区：
文献类型：
--
作者：
Martinez-Camblor, Pablo;Carlos Pardo-Fernandez, Juan
受试者操作特征（ROC）曲线及其相关的汇总指数，例如Youden指数，是常用于分析（生物）标记物区分两个群体的区分能力的统计工具。本文提出了非单调关系的广义ROC（gROC）曲线的背景下的Youden指数的概念。在参数（副正态）和非参数设置的Youden指数和相关的截止点的区间估计被认为是。蒙特卡洛模拟和现实世界的应用程序说明了所提出的方法。
The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker to distinguish between two populations. This paper presents the concept of Youden index in the context of the generalized ROC (gROC) curve for non-monotone relationships. The interval estimation of the Youden index and the associated cutoff points in a parametric (binormal) and a non-parametric setting is considered. Monte Carlo simulations and a real-world application illustrate the proposed methodology.