Prevalence of congenital anomalies in newborns with congenital heart disease diagnosis.
Prevalence of congenital anomalies in newborns with congenital heart disease diagnosis.
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DOI：
10.4103/0974-2069.132474
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发表时间：
2014-05
影响因子：
0.7
通讯作者：
Srivastava S
中科院分区：
文献类型：
--
作者：
Egbe A;Lee S;Ho D;Uppu S;Srivastava S
已知先天性心脏病（CHD）与其他先天性异常（CA）之间存在相关性。这些关联已被最近产前因素的变化所改变。我们回顾了最大的住院患者住院信息数据库，并分析了常见CHD诊断与其他先天性异常之间的当前关联。病例对照研究设计。我们回顾了1998年至2008年的全国住院患者样本（NIS）数据库，并确定了所有诊断为CHD的活产（病例）和未诊断为CHD的活产（对照）。我们比较了病例组和对照组之间相关先天性畸形的患病率。我们的队列分别包括病例组和对照组的97，154和12，078，482例受试者。在CHD人群中，非综合征性先天性异常（NSCA）、遗传综合征（GS）和总体心外先天性异常（CA）的患病率分别为11.4%、2.2%和13.6%。在对照组中，NSCA、GS和CA的患病率分别为6.7%、0.3%和7.0%。NSCA（比值比（OR）：GS（OR：2.52，CI：2.44-2.61）和总CA（OR：2.01，CI：1.97-2.14）与CHD密切相关。GS和多器官系统CA的患病率在研究期间显著下降。这是评估新生儿CHD和心外畸形（ECM）之间关联的最大和最全面的基于人群的研究。在研究期间，GS和多发性CA的患病率显著降低。
There is a known association between congenital heart disease (CHD) and other congenital anomalies (CA). These associations have been altered by changes in prenatal factors in recent time. We reviewed the largest database of inpatient hospitalization information and analyzed the current association between common CHD diagnoses and other congenital anomalies. Case-control study design. We reviewed the Nationwide Inpatient Sample (NIS) database from 1998 to 2008 and identified all live births with CHD diagnosis (case) and live births without CHD diagnosis (control). We compared prevalence of associated congenital anomalies between the case and control groups. Our cohort consisted of 97,154 and 12,078,482 subjects in the case and control groups, respectively. In the CHD population, prevalence of non-syndromic congenital anomaly (NSCA), genetic syndrome (GS), and overall extra-cardiac congenital anomaly (CA) were 11.4, 2.2, and 13.6%, respectively. In the control group, prevalence of NSCA, GS, and CA were 6.7, 0.3, and 7.0%, respectively. NSCA (odds ratio (OR): 1.88, confidence interval (CI): 1.73-1.94), GS (OR 2.52, CI 2.44-2.61), and overall CA (OR: 2.01, CI: 1.97-2.14) were strongly associated with CHD. Prevalence of GS and multiple organ-system CA decreased significantly over the study period. This is the largest and most comprehensive population-based study evaluating association between CHD and extra-cardiac malformation (ECM) in newborns. There was significant decrease in prevalence of GS and multiple CA over the study period.