ICG fluorescence endoscope for visualization of the placental vascular network
ICG fluorescence endoscope for visualization of the placental vascular network
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DOI：
10.1080/13645700802655661
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发表时间：
2009-01-01
影响因子：
1.7
通讯作者：
Chiba, Toshio
中科院分区：
文献类型：
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作者：
Harada, Kanako;Miwa, Mitsuharu;Chiba, Toshio
双胎输血综合征(TTTS)的宫内激光治疗需要对胎盘血管吻合进行准确的原位识别。由于传统的手术方法高度依赖于操作者的技能和经验，我们开发了一种新的方法，通过刚性荧光内窥镜结合静脉注射吲哚青绿(ICG)来显示胎盘血管网络。用猴胎盘和妊娠大鼠检验了荧光内窥镜的可行性。ICG荧光内窥镜即使在羊水混浊的情况下也能详细显示胎盘血管网络。因此，在TTTS的治疗过程中，这种方法对于原位确定胎盘血管吻合有潜在的帮助。此外，我们的硬式荧光内窥镜也将是一种有用的工具，利用ICG进行内窥镜手术的淋巴清扫。
Intrauterine laser photocoagulation for twin-twin transfusion syndrome (TTTS) needs accurate in-situ recognition of placental vascular anastomosis. Because the conventional procedure is highly dependent upon the operators' skill and experience, we developed a new way to visualize the placental vascular network by a rigid-type fluorescence endoscope coupled with intravenous administration of Indocyanine green (ICG). The feasibility of the fluorescence endoscope was examined with monkey placentas and pregnant rats. The ICG fluorescence endoscope can visualize the placental vascular network in detail even in the presence of turbid amniotic fluid. Thus, this method is potentially useful for in-situ definition of the placental vascular anastomoses during the treatment for TTTS. In addition, our rigid-type fluorescence endoscope will also be a useful tool for lymph node dissection using ICG by endoscopic surgery.