Reversible tetracaine block of rat periaqueductal gray (PAG) decreases baseline tail-flick latency and prevents analgesic effects of met-enkephalin injections in nucleus paragigantocellularis (PGC).
Reversible tetracaine block of rat periaqueductal gray (PAG) decreases baseline tail-flick latency and prevents analgesic effects of met-enkephalin injections in nucleus paragigantocellularis (PGC).
复制标题
大鼠导水管周围灰质 (PAG) 的可逆丁卡因阻滞可减少基线甩尾潜伏期，并防止副巨细胞核 (PGC) 注射甲硫脑啡肽的镇痛作用。
DOI：
10.1016/0006-8993(93)91356-w
复制
发表时间：
1993
期刊：
影响因子：
2.9
通讯作者：
Xia,LY
中科院分区：
文献类型：
--
作者：
Rosenfeld,JP;Xia,LY
在大鼠中脑导水管周围灰质注射1μg丁卡因9min可引起肾上腺素的甩尾潜伏期(痛觉过敏)从约5 S增加到3.5 S，之后潜伏期增加到约4.5 S.在中脑导水管周围灰质注射1μg甲硫氨酸脑啡肽可使潜伏期(镇痛)在9分钟从4.2 5增加到6.2 S，15min后恢复到4.7 S。同时给予上述两种纳米注射可完全阻断PGC的镇痛作用。PAG内注射对照和PGC内注射甲硫氨酸脑啡肽并不阻断后者的镇痛作用。PAG或PGC单独注射人工脑脊液无效。PAG的痛敏效应支持PAG参与正常发生的紧张性下行疼痛抑制。在PAG内远距离注射丁卡因阻断PGC甲硫氨酸脑啡肽的镇痛作用，支持PAG的完整性对PGC的镇痛作用的必要性。
One μg of tetracaine in the rat periaqueductal gray (PAG) produced adeclinein baseline tail-flick latencies (hyperalgesia) from about 5 to 3.5 s over the course of 9 min, after which the latencies increased to about 4.5 s. One μg of Met-enkephalin in PGC caused an expected increase in latencies (analgesia) from about 4.25 to 6.2 s in 9 min, with recovery to 4.7 s after 15 min post-injection. Giving the preceding 2 nanoinjectionssimultaneouslyled to an essentially total block of the PGC analgesia. A control injection in PAG simultaneous with a Met-enkephalin injection in PGC didnotblock the latter's analgesic effect. Single control (artificial cerebrospinal fluid) injections in PAG or PGC were without effect. The hyperalgesic effect of PAG tetracain supports the involvement of PAG in normally occuring, tonic descending pain inhibition. The block of PGC met-enkephalin analgesia by distant injection of tetracaine in PAG supports the necessity of PAG integrity for PGC analgesic function.