Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity.
Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity.
复制标题
日本人的肝脏乙醇脱氢酶：非典型形式的高人群频率及其在酒精敏感性中的可能作用。
DOI：
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复制
发表时间：
1975
影响因子：
9.8
通讯作者：
M. Fukui
中科院分区：
文献类型：
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作者：
G. Stamatoyannopoulos;S. Chen;M. Fukui
Electrophoretic and quantitative studies reveal that 85% of Japanese carry an atypical liver alcohol dehydrogenase (ADH). The frequency of ADH polymorphism is identical with the reported frequency of alcohol sensitivity in the Japanese population. This identity in population frequencies points to a causative relationship between the two phenomena and suggests that alcohol sensitivity might be due to the increased acetaldehyde formation in individuals carrying the atypical ADH gene.
