Development of a Patch-Type Flexible Oxygen Partial Pressure Sensor
Development of a Patch-Type Flexible Oxygen Partial Pressure Sensor
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DOI：
10.1109/jtehm.2020.3005477
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发表时间：
2020-01-01
影响因子：
3.4
通讯作者：
Tsukada, Kosuke
中科院分区：
文献类型：
--
作者：
Katayama, Yuta;Fujioka, Yuta;Tsukada, Kosuke
活生物体中的氧浓度是急救护理和床边医疗环境中的重要生命指标之一。然而，血氧测定法具有局限性：测量部位仅限于含有血液的组织，无法测量氧浓度的绝对值。为了克服这些限制，在这项工作中，我们开发了一种新的氧传感器，可以直接测量身体和器官表面的氧粒子压力（pO（2））。将发光二极管（LED）和光电二极管（PD）嵌入与碳纳米管混合的二甲基聚硅氧烷衬底中。使用校准、弯曲应变测试、时间和频率响应以及最后的体内评估来评价器械的有效性。实验结果表明，所制作的氧传感器具有较高的灵敏度.碳纳米管电极具有足够的抗弯曲性，不会影响LED和PD的响应特性，即不会影响氧气测量。体内实验结果表明，所研制的贴片式柔性氧传感器可以通过贴附在具有不规则或曲面的组织或器官上来准确测量pO（2），在大鼠肝脏表面的实际测量结果证明了其可行性。
Oxygen concentration in living organisms is one of the important vital indicators in emergency care and bedside medical settings. However, the oximetry method has limitations: the measurement site is limited to the tissue containing blood and the absolute value of oxygen concentration cannot be measured. To overcome these limitations, in this work, we develop a new oxygen sensor that can directly measure the oxygen particle pressure (pO(2)) on the surface of the body and organs. A light emitting diode (LED) and a photodiode (PD) were embedded in a dimethylpolysiloxane substrate mixed with carbon nanotubes. The effectiveness of the device was evaluated using calibration, bending strain tests, time and frequency response, and finally in vivo assessments. The results reveal that the calibration experiment of the fabricated oxygen sensor device showed high sensitivity. The carbon nanotube electrode has a sufficient bending resistance and does not affect the response characteristics of the LED and PD, that is, it does not affect the oxygen measurement. In vivo assessment shows that the developed patch-type flexible oxygen sensor can accurately measure pO(2) by attaching it to tissues or organs having irregularities or curved surfaces and actual measurements on rat liver surface demonstrated its feasibility.