Review and discussion of tubular biomarkers in the diagnosis and management of diabetic nephropathy.
Review and discussion of tubular biomarkers in the diagnosis and management of diabetic nephropathy.
复制标题
DOI：
10.1007/s12020-012-9820-y
复制
发表时间：
2013-06
期刊：
影响因子：
3.7
通讯作者：
Kanwar, Yashpal S.
中科院分区：
文献类型：
--
作者：
Tramonti, Gianfranco;Kanwar, Yashpal S.
过去几十年来，随着糖尿病发病率的不断上升，糖尿病肾病的患病率也急剧增加。糖尿病肾病是发病率和死亡率的主要原因，并且它总是会导致终末期肾病（ERSD）。为了延缓 ESRD 的发生，需要系统筛查和适当的管理来评估糖尿病肾病肾损伤的进展。目前的测试在预测糖尿病肾病的发病、进展和对各种治疗方案的反应方面的可靠性仍存在争议。人们开始寻找更敏感和更特异的尿液生物标志物，特别是那些反映肾小管功能障碍的生物标志物。众所周知，肾小管间质损伤程度与肾功能恶化之间存在良好的相关性。鉴于此，本文简要回顾了文献中报道的反映肾小管损伤的尿液生物标志物的实用性。
The prevalence of diabetic nephropathy has tremendously increased with the relentless rise in the incidence of diabetes over the last couple decades. Diabetic nephropathy is a leading cause of morbidity and mortality, and it invariably leads to an end stage renal disease (ERSD). In an effort to delay the onset of ESRD systematic screening and appropriate management are needed to evaluate the progression of renal damage in diabetic nephropathy. The reliability of current tests in predicting the onset, progression and response to various regimens for diabetic nephropathy is still under debate; and it has engendered a search for more sensitive and specific urinary biomarkers, especially those reflective of tubular dysfunctions. It is well known that there is a good correlation between the degree of damage to the tubulo-interstitial compartment and the deterioration of renal functions. In view of this, the utility of urinary biomarkers, reflective of tubular injury, reported in the literature is discussed in this brief review.
登录
查看更多内容
影响因子：
4.9
作者：
Fabris, B;Candido, R;Carretta, R
通讯作者：
Carretta, R
影响因子：
2.8
作者：
Bolignano, Davide;Lacquaniti, Antonio;Buemi, Michele
通讯作者：
Buemi, Michele
尿色素上皮衍生因子作为糖尿病肾病的标志物
影响因子：
4.2
作者：
Chen, Haibing;Zheng, Zhi;Jia, Weiping
通讯作者：
Jia, Weiping
影响因子：
5.1
作者：
Fu, Wen-Jin;Li, Bao-Liang;Wang, Qian
通讯作者：
Wang, Qian
影响因子：
4.2
作者：
Coughlan, Melinda T.;Patel, Sheila K.;Forbes, Josephine M.
通讯作者：
Forbes, Josephine M.