Apolipoprotein E and mimetic peptide initiate a calcium‐dependent signaling response in macrophages
Apolipoprotein E and mimetic peptide initiate a calcium‐dependent signaling response in macrophages
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载脂蛋白 E 和模拟肽在巨噬细胞中启动钙依赖性信号传导反应
DOI：
10.1189/jlb.70.4.677
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发表时间：
2001
影响因子：
5.5
通讯作者：
D. Laskowitz
中科院分区：
文献类型：
--
作者：
U. K. Misra;C. Adlakha;G. Gawdi;M. McMillian;S. Pizzo;D. Laskowitz
Apolipoprotein E (ApoE) is a 34‐kDa cholesterol transport protein that also possesses immunomodulatory properties. In this study, we demonstrate that ApoE initiates a signaling cascade in murine peritoneal macrophages that leads to increased production of inositol triphosphate with mobilization of intracellular Ca2+ stores. This cascade is inhibited by pretreatment with receptor‐associated protein and Ni2+, and it is mediated by a pertussis toxin‐sensitive G protein. These properties are characteristic of signal transduction induced via ligand binding to the cellular receptor, lipoprotein receptor‐related protein. A peptide derived from the receptor‐binding region of ApoE also initiates signal transduction in a manner similar to that of the intact protein, suggesting that this isolated region is sufficient for signal transduction. The ApoE‐mimetic peptide competed for binding with the intact protein, confirming that they both interact with the same site. ApoE‐dependent signal transduction might play a role in mediating the functional properties of this lipoprotein.
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镍是活性α2-巨球蛋白与低密度脂蛋白受体相关蛋白/α2-巨球蛋白受体结合的特异性抑制剂。
影响因子：
2.9
作者：
Hussain,MM;Kancha,RK;Tulenko,TN
通讯作者：
Tulenko,TN
DOI：
--
发表时间：
1980
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hui,DY;Harmony,JA;Innerarity,TL;Mahley,RW
通讯作者：
Mahley,RW
α2-巨球蛋白受体和低密度脂蛋白受体相关蛋白之间的序列同一性表明该分子是多功能受体。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Strickland,DK;Ashcom,JD;Williams,S;Burgess,WH;Migliorini,M;Argraves,WS
通讯作者：
Argraves,WS
DOI：
10.1161/01.atv.14.12.2025
发表时间：
1994-12-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
JI, ZS;MAHLEY, RW
通讯作者：
MAHLEY, RW
影响因子：
56.9
作者：
NATHAN, BP;BELLOSTA, S;PITAS, RE
通讯作者：
PITAS, RE