Antiandrogenic phenolic constituents from Dalbergia cochinchinensis
Antiandrogenic phenolic constituents from Dalbergia cochinchinensis
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DOI：
10.1016/s0031-9422(97)80015-5
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发表时间：
1997-12-01
期刊：
影响因子：
3.8
通讯作者：
Satake, M
中科院分区：
文献类型：
--
作者：
Pathak, V;Shirota, O;Satake, M
从交趾黄檀 (Dalbergia cochinchinensis) 的茎中分离出 4 种新化合物，即 9-羟基-6,7-二甲氧基降香醇、6-羟基-2,7-二甲氧基新黄烯、6,4'-二羟基-7-甲氧基黄烷和 2,2',5-三羟基-4-甲氧基二苯甲酮，以及包括 7-羟基-6-甲氧基黄酮在内的八种已知酚类化合物。它们的结构是通过光谱技术（包括一维和二维核磁共振方法）确定的。前两种化合物对 5α-二氢睾酮 (DHT) 显示出有效的抑制活性，5α-二氢睾酮 (DHT) 与雄激素受体结合形成 DHT 受体复合物，导致雄激素依赖性疾病。 (C) 1997 爱思唯尔科学有限公司。
Four new compounds, 9-hydroxy-6,7-dimethoxydalbergiquinol, 6-hydroxy-2,7-dimethoxy-neoflavene, 6,4'-dihydroxy-7-methoxyflavan and 2,2',5-trihydroxy-4-methoxybenzophenone, in addition to eight known phenolic compounds including 7-hydroxy-6-methoxyflavone, have been isolated from the stems of Dalbergia cochinchinensis. Their structures were established by spectroscopic techniques including one-and two-dimensional NMR methods. The first two compounds showed potent inhibitory activity towards 5 alpha-dihydrotestosterone (DHT) which binds with an androgen receptor to form a DHT-receptor complex that causes androgen-dependent diseases. (C) 1997 Elsevier Science Ltd.