Visualization of specific angiotensin II binding sites in the brain by fluorescent microscopy.
Visualization of specific angiotensin II binding sites in the brain by fluorescent microscopy.
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DOI：
10.1126/science.6254147
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发表时间：
1980-11
期刊：
影响因子：
56.9
通讯作者：
S. Landas;M. Phillips;J. Stamler;M. Raizada
中科院分区：
文献类型：
--
作者：
S. Landas;M. Phillips;J. Stamler;M. Raizada
终板的血管器被认为是介导血管紧张素II中枢反应的受体的部位。到目前为止，这是基于间接证据，但现在已经通过使用生物活性的荧光血管紧张素II激动剂实现了对血管紧张素II作用部位的直接可视化。终板血管器的心室表面显示出强烈的荧光，这种荧光实际上被过量的未标记血管紧张素II消除。
The organum vasculosum of the lamina terminalis has been implicated as the site of receptors mediating central responses of angiotensin II. Up to now, this had been based on indirect evidence, but direct visualization of angiotensin II at its site of action has now been achieved by the use of a biologically active fluorescent angiotensin II agonist. The ventricular surface of the organum vasculosum lamina terminalis showed intense fluorescence, which was virtually eliminated by an excess of unlabeled angiotensin II.