Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder.
Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder.
复制标题
DOI：
10.3389/fnbeh.2015.00333
复制
发表时间：
2015
影响因子：
3
通讯作者：
Neylan TC
中科院分区：
文献类型：
--
作者：
Chao LL;Tosun D;Woodward SH;Kaufer D;Neylan TC
最近的研究结果表明，髓鞘在中枢神经系统中的少突胶质细胞的形成是一个连续的过程，可以修改的经验。例如，最近的一项研究表明，固定压力增加了成年大鼠海马齿状回的少突神经元生成。因为髓鞘形成的变化代表了大脑可塑性的一种适应性形式，它在成人大脑中的影响范围比其他形式的可塑性更大（例如，神经发生），这项“概念验证”研究的目的是检查患有和不患有创伤后应激障碍（PTSD）的人的大脑中髓鞘形成是否存在差异。我们使用T1加权/T2加权磁共振成像（MRI）强度的比值来估计19名患有PTSD的男性退伍军人和19名匹配的创伤暴露的男性退伍军人（平均年龄：43 ± 12岁）的海马髓鞘形成程度。我们发现，与创伤后应激障碍的退伍军人有显着更多的海马髓鞘比创伤暴露的控制。研究还发现海马髓鞘形成和PTSD与抑郁症状严重程度之间存在正相关。据我们所知，这是第一个研究PTSD患者海马髓鞘形成的研究。这些结果为应激诱导的海马髓鞘形成作为与应激易感性相关的脑异常的潜在机制提供了初步证据。
Recent findings suggest the formation of myelin in the central nervous system by oligodendrocytes is a continuous process that can be modified with experience. For example, a recent study showed that immobilization stress increased oligodendrogensis in the dentate gyrus of adult rat hippocampus. Because changes in myelination represents an adaptive form of brain plasticity that has a greater reach in the adult brain than other forms of plasticity (e.g., neurogenesis), the objective of this “proof of concept” study was to examine whether there are differences in myelination in the hippocampi of humans with and without post-traumatic stress disorder (PTSD). We used the ratio of T1-weighted/T2-weighted magnetic resonance image (MRI) intensity to estimate the degree of hippocampal myelination in 19 male veterans with PTSD and 19 matched trauma-exposed male veterans without PTSD (mean age: 43 ± 12 years). We found that veterans with PTSD had significantly more hippocampal myelin than trauma-exposed controls. There was also found a positive correlation between estimates of hippocampal myelination and PTSD and depressive symptom severity. To our knowledge, this is the first study to examine hippocampal myelination in humans with PTSD. These results provide preliminary evidence for stress-induced hippocampal myelin formation as a potential mechanism underlying the brain abnormalities associated with vulnerability to stress.