Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
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DOI：
10.1039/b924519g
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Schofield, Christopher J.
中科院分区：
文献类型：
--
作者：
Hamed, Refaat B.;Mecinovic, Jasmin;Schofield, Christopher J.
The utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the corresponding bicyclic beta-lactams by a carbapenem synthetase.
