Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons
Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons
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切断的周围神经轴突中持续活动、机械敏感性和肾上腺素敏感性的发展
DOI：
10.1016/0014-4886(81)90271-5
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发表时间：
1981
影响因子：
5.3
通讯作者：
J. Scadding
中科院分区：
文献类型：
--
作者：
J. Scadding
在切断的周围神经轴突中出现了几种异常特性。其中三个，正在进行的活动，机械敏感性和肾上腺素敏感性记录在单纤维近端的实验神经瘤产生的坐骨神经横断小鼠。使用取样技术，在41只小鼠中，在神经切断后的不同时间，从1小时到7周的范围内，测量显示这些异常特性的有髓纤维的百分比。神经切断后24小时首次出现异常传入活动，3天后出现持续活动、机械和肾上腺素敏感性的早期峰值。随后是一个更晚的，更大的活动高峰，从大约14到21天。21天后活动减少，至少持续到7周。神经瘤的最大传入弹幕期间，前28天，正好与神经切断后的期间，在此期间发生的麻醉足最大自残。有人提出，有一个因果关系之间的传入阻滞从神经瘤和截肢的麻醉足，传入冲动从类似的神经病变在人可能是负责的疼痛和感觉异常，可能会导致这种病变。
Several abnormal properties develop in severed peripheral nerve axons. Three of these, ongoing activity, mechanical sensitivity, and adrenaline sensitivity were recorded in single fibers proximal to experimental neuromas produced by sciatic nerve transection in mice. Using a sampling technique, the percentages of myelinated fibers showing these abnormal properties were measured in 41 mice at various times after nerve transection, ranging from 1 h to 7 weeks. Abnormal afferent activity was first seen 24 h after nerve transection, with an early peak of ongoing activity, mechanical and adrenaline sensitivity, at 3 days. This was followed by a later, larger peak of activity from about 14 to 21 days. Activity after 21 days decreased which continued at least until 7 weeks. The period of maximum afferent barrage from neuromas, before 28 days, coincided with the period after nerve transection during which maximum self-mutilation of the anesthetic foot occured. It is proposed that there is a causal relationship between the afferent barrage from neuromas and mutilation of the anesthetic foot, and that afferent impulses from similar nerve lesions in man may be responsible for pain and paresthesiae that may result from such lesions.