Summary and Future Research Needs
Summary and Future Research Needs
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DOI：
10.2307/3428990
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发表时间：
1980-04
影响因子：
10.4
通讯作者：
P. Bromberg;D. Menzel
中科院分区：
文献类型：
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作者：
P. Bromberg;D. Menzel
布罗姆伯格博士：这是一次值得注意的会议，除了极少数例外，几乎没有提到肺力学和气体交换。这种情况在专门讨论肺部研究的会议上并不经常发生，但最近可能发生得更频繁，这可能预示着未来的趋势。另一个有趣的注意是，几乎每个人都在与超微结构学家合作，或者希望获得超微结构技术。Reid博士和其他人一起，给我们很好地演示了超微结构技术如何与生化技术相结合，用于肺对损伤反应的实验研究。Satir博士提出了关于纤毛运动机制的最优雅的超微结构生化数据。据我所知，会议的组织将肺分为三个部分。有一个大面积的关注上皮，并在年底，有一个大面积的关注内皮。在中间，我想适当地，有一些演讲者谈论细胞或多或少地适合上皮和内皮之间。值得注意的是，或在很大程度上缺失的是超过及格水平的平滑肌和神经功能的讨论。Boucher博士和Gatzy博士确定了上皮切片的基调，他们指出了上皮的屏障功能，并试图定量该屏障的性质和部位。他们特别关注细胞间连接和所谓的上皮紧密连接，并通过电学测量和使用各种不带电的探针分子来定义它们的特性。
Dr. Bromberg: This is a remarkable meeting in that, with very few exceptions, almost no mention was made of pulmonary mechanics and of gas exchange. That doesn't happen very often in meetings devoted primarily to lung research, but perhaps has been happening more frequently in the recent past and it may indicate a trend for the future. Another interesting note was that almost everyone is working or collaborating with an ultrastructuralist, or would like to have access to ultrastructural techniques. Dr. Reid, among others, gave us a very nice demonstration of how ultrastructural techniques can be combined with biochemical techniques in experimental studies of the reaction of the lung to insults. Dr. Satir presented most elegant ultrastructural biochemical data on the mechanism of ciliary motion. The organization of the meeting, as I perceive it, looks at the lung as having three segments. There was a large area of attention to the epithelium, and at the end, there was a large area of attention to the endothelium. In the middle, I suppose appropriately, there were a number of speakers who talked about cells that more or less fit between the epithelium and the endothelium. Notably missing, or in large measure missing, were discussions of smooth muscle and of neural function at more than a passing level. The keynote of the epithelial sections was set by Dr. Boucher and Dr. Gatzy, who pointed to the barrier function of the epithelium and the attempts to quantitate the nature and the site of this barrier. They paid special attention to the intercellularjunctions and the so-called tight junctions of the epithelium and defined their properties by electrical measurements and by using a variety of non-charged probe molecules.