Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors
Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors
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海藻酸钠功能化纳米金刚石作为持续化疗药物释放载体
DOI：
10.1016/j.carbon.2015.07.066
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发表时间：
2016-02-01
期刊：
影响因子：
10.9
通讯作者：
Zhu, Ying
中科院分区：
文献类型：
--
作者：
Cui, Zhifen;Zhang, Yu;Zhu, Ying
在设计理想的药物递送系统时，单剂量在延长的时间段内延长治疗作用是至关重要的。基于纳米颗粒的药物载体是一种理想的药物递送技术，然而，由于潜在的安全性问题和短暂的药物滞留，它们的利用仍然存在争议。纳米金刚石（NDs），具有良好的生物相容性和多样性的潜在共轭物，已成为替代有前途的材料在这方面。在这里，我们开发了海藻酸钠功能化ND（fND）的药物输送。选择顺铂（DDP）作为模型药物并将其涂覆在带负电荷的fND簇上。我们的工作表明，fND能够增加药物在肿瘤细胞中的积累和保留时间，导致药物治疗清除后持续的肿瘤细胞杀伤作用。此外，与DDP治疗相比，fNDs-DDP治疗改善了药物安全性。因此，这种新的平台可能具有进一步生物医学应用的强大潜力。(C)2015爱思唯尔有限公司版权所有。
Prolonged therapeutic action over an extended period of time on single dose is vital in designing an ideal drug delivery system. Nanoparticle-based vehicles for drug delivery serves as an ideal technology, however, utilization of them remains controversial due to potential safety concerns and transient drug retention. Nanodiamonds (NDs), with excellent biocompatibility and diversity of potential conjugates, have emerged as alternative promising materials in this regard. Here, we developed sodium alginate functionalized NDs (fNDs) for drug delivery. Cisplatin (DDP) was chosen as a model drug and coated on the negatively charged fNDs clusters. Our work demonstrated that fNDs were capable of enhancing drug accumulation and retention time in tumor cells, leading to continued tumor cell killing effect after clearance of drug treatment. Furthermore, fNDs-DDP treatment improved drug safety compared to DDP treatment. Thus, this new platform may have strong potential for further biomedical application. (C) 2015 Elsevier Ltd. All rights reserved.