LOCAL AND REMOTE MODIFICATIONS OF NOCICEPTIVE SENSITIVITY DURING CARRAGEENAN-INDUCED INFLAMMATION IN THE RAT
LOCAL AND REMOTE MODIFICATIONS OF NOCICEPTIVE SENSITIVITY DURING CARRAGEENAN-INDUCED INFLAMMATION IN THE RAT
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DOI：
10.1016/0304-3959(87)91064-5
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发表时间：
1987-01-01
期刊：
影响因子：
7.4
通讯作者：
GUILBAUD, G
中科院分区：
文献类型：
--
作者：
KAYSER, V;GUILBAUD, G
在大鼠足底注射多糖角叉胶后，在不同时间（15 分钟至 96 小时）监测由爪子（后爪和前爪）压力引起的发声阈值的变化。在注射角叉菜胶后的前 2 小时内，不仅观察到注射后右爪的发声阈值降低，而且在一些大鼠中，远离发炎足底区域的爪子（尤其是右前爪）也观察到发声阈值降低。通过在右后爪局部施用赛洛卡因来抑制这种痛觉过敏作用。注射后4天内，注射爪子中痛觉过敏的大鼠数量逐渐减少。注射角叉菜胶24小时后，只有少数大鼠未注射的爪子仍表现出明显的痛觉过敏。
The modifications of the threshold for vocalization induced by pressure on the paws (both hind paws and both forepaws) were monitored at different times (15 min-96 h) following intraplantar injection of the polysaccharide carrageenin in the rat. During the first 2 h following the carrageenin injection, a decrease in vocalization threshold was observed not only for the right, injected hind paw, but also, in some rats, on paws distant from the inflamed plantar region, especially the right forepaw. This hyperalgesic effect was suppressed by locally administered Xylocaine into the right hind paw. During the 4 days following the injection, the number of rats hyperalgesic in the injected paw progressively declined. Twenty-four hours after the carrageenin injection, only a few rats still presented a clear hyperalgesia in the non-injected paws.