Electrospinning fabrication of covalent organic framework composite nanofibers for pipette tip solid phase extraction of tetracycline antibiotics in grass carp and duck
Electrospinning fabrication of covalent organic framework composite nanofibers for pipette tip solid phase extraction of tetracycline antibiotics in grass carp and duck
复制标题
静电纺丝法制备共价有机骨架复合纳米纤维，用于草鱼和鸭体内四环素抗生素的固相萃取。
DOI：
10.1016/j.chroma.2020.461098
复制
发表时间：
2020-07-05
影响因子：
4.1
通讯作者：
Yan, Zhiming
中科院分区：
文献类型：
--
作者：
Wang, Ronglin;Li, Canru;Yan, Zhiming
采用静电纺丝法制备了一种新型的共价有机骨架COF-SCU 1静电纺丝纳米纤维（PAN@ COF-SCU 1 nanofibers），并将其作为吸附剂用于食品中四环素类抗生素的固相萃取（PT-SPE）。所制备的PAN@ COF-SCU 1纳米纤维同时具有静电纺丝纳米纤维和COFS-CU 1的特性，提高了静电纺丝纳米纤维的吸附能力，避免了直接使用纳米COFs作为吸附剂在PT-SPE中产生的泄漏和高压问题。考察了COFS-CU 1在纳米纤维中的负载率、纳米纤维的用量、基质pH值和脱附溶剂等因素对吸附和脱附效果的影响。最后，建立了一种新的移液器固相萃取-高效液相色谱（PT-SPE/HPLC）分析食品中3种TC的方法。在4-70 ng/mL范围内，线性关系良好。检测限和定量限范围分别为0.6 - 3 ng/mL（-1）和2 - 10 ng/mL（-1）。日内、日间精密度（RSD）均小于9%。首次将所建立的PT-SPE/HPLC方法应用于草鱼和鸭样品中TCs残留量的测定。本研究不仅探索了PT-SPE在食品样品中TC提取中的可行性，而且拓宽了COFs在样品前处理中的应用前景。(C)2020 Elsevier B. V.保留所有权利。
In the current study, a novel covalent organic frameworks COF-SCU1 incorporated electrospun nanofibers (PAN@COF-SCU1 nanofibers) was fabricated via a facile electrospinning method and utilized as adsorbent in pipette tip solid-phase extraction (PT-SPE) of tetracycline antibiotics (TCs) from foods. The prepared PAN@COF-SCU1 nanofibers possessed both of the unique characteristics of electrospun nanofibers and COFS-CU1, and thus improving the adsorption capacity of the electrospun nanofibers and preventing the problems of leakage and high pressure caused by directly using the nanosize COFs as adsorbent in PT-SPE. The experiments affected the adsorption and desorption efficiencies, such as the loading ratios of COFS-CU1 in nanofibers, the amount of nanofibers, the matrix pH and desorption solvent, were studied in detail. Eventually, a new pipette tip solid-phase extraction-high performance liquid chromatography (PT-SPE/HPLC) method was proposed for the analysis of three TCs from food. Satisfied linearity for TCs was obtained in the range of 4-70 ng mL(-1). The limits of detection and quantification were ranged from 0.6 to 3 ng mL(-1) and from 2 to 10 ng mL(-1), respectively. The interday and intraday precisions (RSD) were all lower than 9%. The proposed PT-SPE/HPLC method was used to determine TCs residues in grass carp and duck samples for the first time. The results could not only explore the availability of PT-SPE in the extraction of TCs in food samples, but also broadened the potential applications of COFs in sample preparation. (C) 2020 Elsevier B.V. All rights reserved.