Sustained suppression of neointimal proliferation by sirolimus-eluting stents - One-year angiographic and intravascular ultrasound follow-up
Sustained suppression of neointimal proliferation by sirolimus-eluting stents - One-year angiographic and intravascular ultrasound follow-up
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DOI：
10.1161/hc4201.098056
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发表时间：
2001-10-23
期刊：
影响因子：
37.8
通讯作者：
Serruys, PW
中科院分区：
文献类型：
--
作者：
Sousa, JE;Costa, MA;Serruys, PW
背景-我们之前曾报道，植入西罗莫司洗脱支架 4 个月后，几乎没有新内膜增生。本研究的目的是确定这些结果是否能持续 1 年。 方法和结果 - 巴西圣保罗（n = 30，其中 15 名快速释放 [组 I，GI] 和 15 名缓慢释放 [GII]）和荷兰鹿特丹（15 名缓慢释放，GIII）植入单个西罗莫司洗脱 Bx VELOCITY 支架，成功治疗了 45 名新发冠心病患者。在 4 个月和 12 个月（GI 和 GII）以及 6 个月（GIII）时进行血管造影和容积血管内超声 (IVUS) 随访。所有组中支架内最小管腔直径和直径狭窄百分比基本保持不变（12 个月时，GI 和 GII；6 个月时，GIII）。随访病变内最小管腔直径为 2.28 mm (GIII)、2.32 mm (GI) 和 2.48 mm (GII)。通过血管造影或 IVUS 评估，没有患者在 I 年时接近大于或等于 50% 直径狭窄，并且没有观察到边缘再狭窄。通过 IVUS 检测到，新内膜增生在 6 个月（2 +/-5% 阻塞体积，GIII）和 12 个月（GI=2 +/-5% 和 GII=2 +/-3%）时几乎不存在。结论 - 这项研究表明，西罗莫司洗脱 Bx VELOCITY 支架在植入 1 年后持续抑制新内膜增殖。
Background-We have previously reported a virtual absence of neointimal hyperplasia 4 months after implantation of sirolimus-eluting stents. The aim of the present investigation was to determine whether these results are sustained over a period of 1 year.Methods and Results-Forty-five patients with de novo coronary disease were successfully treated with the implantation of a single sirolimus-eluting Bx VELOCITY stent in Sao Paulo, Brazil (n=30, 15 fast release [group I, GI] and 15 slow release [GII]) and Rotterdam, The Netherlands (15 slow release, GIII). Angiographic and volumetric intravascular ultrasound (IVUS) follow-up was obtained at 4 and 12 months (GI and GII) and 6 months (GIII). In-stent minimal lumen diameter and percent diameter stenosis remained essentially unchanged in all groups (at 12 months, GI and GII; at 6 months, GIII). Follow-up in-lesion minimal lumen diameter was 2.28 mm (GIII), 2.32 mm (GI), and 2.48 mm (GII). No patient approached the greater than or equal to 50% diameter stenosis at I year by angiography or IVUS assessment, and no edge restenosis was observed. Neointimal hyperplasia, as detected by IVUS, was virtually absent at 6 months (2 +/-5% obstruction volume, GIII) and at 12 months (GI=2 +/-5% and GII=2 +/-3%).Conclusions-This study demonstrates a sustained suppression of neointimal proliferation by sirolimus-eluting Bx VELOCITY stents 1 year after implantation.