Relationships between cholesterol, apolipoprotein E polymorphism and dementia: A cross-sectional analysis from the PAQUID study
Relationships between cholesterol, apolipoprotein E polymorphism and dementia: A cross-sectional analysis from the PAQUID study
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DOI：
10.1159/000026249
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发表时间：
2000-05-01
影响因子：
5.7
通讯作者：
Dartigues, JF
中科院分区：
文献类型：
--
作者：
Bonarek, M;Barberger-Gateau, P;Dartigues, JF
本研究评估了血清胆固醇水平和痴呆之间的横断面关系，控制载脂蛋白E（apoE）基因型，在一项嵌套的病例对照研究中，334名73岁及以上的法国老年人参加了PAQUID研究（37名痴呆受试者和297名非痴呆对照），通过两步筛选确定痴呆的诊断：（1）心理测验和DSM-III-R标准;（2）神经科医生的确认。从血液样品中测定胆固醇、其分数和apoE基因型。高密度脂蛋白胆固醇升高与痴呆风险显著降低相关，与apoE状态和其他潜在混杂变量无关，表明胆固醇组分可能与阿尔茨海默病和血管性痴呆有关，Copyright（C）2000 S. Karger AG，巴塞尔。
This study assesses the cross-sectional relationship between serum cholesterol level and dementia, controlling for apolipoprotein E (apoE) genotype, in a nested case-control study of 334 elderly French subjects aged 73 and over who participated in the PAQUID study (37 demented subjects and 297 nondemented controls), A diagnosis of dementia was established by two-step screening: (1) psychometric testing and DSM-III-R criteria and (2) neurologist's confirmation. Cholesterol, its fractions and apoE genotype were determined from a blood sample. Elevated high-density lipoprotein cholesterol was associated with a significantly de-creased risk of dementia, independent of apoE status and other potential confounding variables, suggesting that cholesterol fractions could be involved in both Alzheimer's disease and vascular dementia, Copyright (C) 2000 S. Karger AG, Basel.