Molecular chaperones and quality control in noncoding RNA biogenesis.
Molecular chaperones and quality control in noncoding RNA biogenesis.
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非编码 RNA 生物合成中的分子伴侣和质量控制。
DOI：
10.1101/sqb.2006.71.051
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Wurtmann,EJ
中科院分区：
文献类型：
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作者：
Wolin,SL;Wurtmann,EJ
尽管非编码RNA在所有细胞中都发挥着关键作用，但这些RNA折叠成功能结构的机制以及监控正确折叠的质量控制途径才刚刚开始阐明。在这里，我们讨论了几种可能作为非编码RNA分子伴侣的蛋白质，并回顾了现有的关于非编码RNA质量控制的知识。一种蛋白质，La蛋白，结合了真核生物中许多新生的非编码RNA，是有效折叠某些前tRNA所必需的。在原核生物中，类Sm蛋白Hfq是许多非编码RNA功能所必需的。最近在细菌和酵母方面的工作揭示了质量控制系统的存在，该系统涉及不稳定的非编码RNA的聚腺苷酸化，然后是核外降解。此外，Ro蛋白存在于许多动物细胞和某些细菌中，它与错误折叠的非编码RNA结合，被认为在RNA质量控制中发挥功能。
Although noncoding RNAs have critical roles in all cells, both the mechanisms by which these RNAs fold into functionalstructures and the quality control pathways that monitor correct folding are only beginning to be elucidated. Here, we discussseveral proteins that likely function as molecular chaperones for noncoding RNAs and review the existing knowledge on noncodingRNA quality control. One protein, the La protein, binds many nascent noncoding RNAs in eukaryotes and is requiredfor efficient folding of certain pre-tRNAs. In prokaryotes, the Sm-like protein Hfq is required for the function of many noncodingRNAs. Recent work in bacteria and yeast has revealed the existence of quality control systems involving polyadenylationof unstable noncoding RNAs followed by exonucleolytic degradation. In addition, the Ro protein, which is present inmany animal cells and also certain bacteria, binds misfolded noncoding RNAs and is proposed to function in RNA qualitycontrol.