Correlations between acoustic properties and bone density in bovine cancellous bone from 0.5 to 2 MHz
Correlations between acoustic properties and bone density in bovine cancellous bone from 0.5 to 2 MHz
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DOI：
10.1121/1.1567733
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发表时间：
2003-05-01
影响因子：
2.4
通讯作者：
Yoon, SW
中科院分区：
文献类型：
--
作者：
Lee, KI;Roh, HS;Yoon, SW
本文研究了12个脱脂牛松质骨的声学特性与骨密度的相关性。声速（SOS）和宽带超声衰减（BUA）进行了测量，在三个不同的频率带宽从0.5到2 MHz使用三个匹配的换能器对的中心频率为1，2.25，和3.5 MHz。超声束与骨标本之间的相对方向为牛胫骨的内外侧（ML）方向。SOS显示出显着的线性正相关与表观密度为所有三对传感器。然而，BUA表现出相对较弱的相关性与视密度。SOS和BUA之间只有微弱的相关性。SOS和BUA在多元回归模型中的线性组合导致预测表观密度的显著改善。多元回归模型能在三维空间有效、清晰地表达SOS、BUA和骨密度之间的相关性。这些结果表明，高达1.5 MHz的频率范围和三维空间的多元回归模型可以用于骨质疏松症的诊断。(C)2003年，美国声学学会。
Correlations between acoustic properties and bone density were investigated in the 12 defatted bovine cancellous bone specimens in vitro. Speed of sound (SOS) and broadband ultrasonic attenuation (BUA) were measured in three different frequency bandwidths from 0.5 to 2 MHz using three matched pairs of transducers with the center frequencies of 1, 2.25, and 3.5 MHz. The relative orientation between ultrasonic beam and bone specimen was the mediolateral (ML) direction of the bovine tibia. SOS shows significant linear positive correlation with apparent density for all three pairs of transducers. However, BUA shows relatively weak correlation with apparent density. SOS and BUA are only weakly correlated with each other. The linear combination of SOS and BUA in a multiple regression model leads to a significant improvement in predicting apparent density. The correlations among SOS, BUA, and bone density can be effectively and clearly represented in the three-dimensional space by the multiple regression model. These results suggest that the frequency range up to 1.5 MHz and the multiple regression model in the three-dimensional space can be useful in the osteoporosis diagnosis. (C) 2003 Acoustical Society of America.