The osteogenic effects of porous Tantalum and Titanium alloy scaffolds with different unit cell structure
The osteogenic effects of porous Tantalum and Titanium alloy scaffolds with different unit cell structure
复制标题
不同晶胞结构的多孔钽和钛合金支架的成骨作用。
DOI：
10.1016/j.colsurfb.2021.112229
复制
发表时间：
2021-12-04
影响因子：
5.8
通讯作者：
Qiu, Jia-Xuan
中科院分区：
文献类型：
--
作者：
Huang, Gan;Pan, Shu-Ting;Qiu, Jia-Xuan
Porous scaffolds have long been regarded as optimal substitute for bone tissue repairing. In order to explore the influence of unit cell structure and inherent material characteristics on the porous scaffolds in terms of mechanical and biological performance, selective laser melting (SLM) technology was used to fabricate porous tantalum (Ta) and titanium alloy (Ti6Al4V) with diamond (Di) or rhombic dodecahedron (Do) unit cell structure. The mechanical strength of all the porous scaffolds could match that of trabecular bone, while the biological performance of each scaffold was diverse from each other. Moreover, the ILK/ERK1/2/Runx2 signaling pathway had been verified to be involved in the osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs) cultured on those porous scaffolds. Unit cell structure and material characteristics of the porous Ta and Ti6Al4V scaffolds can synergistically modulate this axis and further impact on the osteogenic effects. Our results hence illustrate that porous Ta scaffold with diamond unit cell structure possesses excellent osteogenic effects and moderate mechanical strength and porous Ti6Al4V scaffold with rhombic dodecahedron unit cell structure has the highest mechanical strength and moderate osteogenic effects. Both porous Ta and Ti6Al4V can be applied in different settings requiring either better biological performance or higher mechanical demand.
