Geographical and temporal differences in the urinary excretion of inorganic arsenic: A Belgian population study
Geographical and temporal differences in the urinary excretion of inorganic arsenic: A Belgian population study
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DOI：
10.1136/oem.53.5.320
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发表时间：
1996-05-01
影响因子：
4.9
通讯作者：
Fagard, R
中科院分区：
文献类型：
--
作者：
Buchet, JP;Staessen, J;Fagard, R
1985 - 1989年，在Cadm-Bel研究中，测量了工业化城市居民24小时尿砷排泄量，作为近期暴露的指标（列日：n = 664，沙勒罗伊：n = 291），在农村控制区（Hechtel-Eksel：n = 397），以及农村地区，那里的人口可能通过饮用水或有色金属冶炼厂的排放而受到影响（Wezel：n = 93，洛梅尔：n = 111，Pelt：n = 133）。在1991 - 1995年的PheeCad研究中，农村地区（n = 609）与城市对照区一起进行了重新检查（鲁汶：结果--镉Bel结果显示，在调整性别、年龄和体重指数后，24小时砷排泄量在列日（91 nmol）、沙勒罗伊（91 nmol）、（155 nmol），Hechtel-Eksel（144 nmol）和Wezel（158 nmol），而最高排泄量见于洛梅尔（570 nmol）和毛皮（373 nmol）。在PheeCad研究期间，农村地区的平均24小时砷排泄量范围为81至111 nmol。这低于6年前，与对照城镇的排泄量（108 nmol）相似。对529名农村居民的纵向研究证实，农村居民24 h砷排泄量下降（P
Objective-This Belgian study assessed the geographical and temporal differences in the exposure of the population to inorganic arsenic, a known carcinogen.Methods-In the CadmiBel study (1985-9) the 24 h urinary arsenic excretion was measured, as an index of recent exposure, in industrialised cities (Liege: n = 664, Charleroi: n = 291), in a rural control area (Hechtel-Eksel: n = 397), and in rural districts in which the population had possibly been exposed through the drinking water or the emissions of nonferrous smelters (Wezel: n = 93, Lommel: n = 111, and Pelt: n = 133). In the PheeCad study, in 1991-5, the rural areas (n = 609) were re-examined together with an urban control area (Leuven: n = 152).Results-The CadmiBel results showed that after adjustment for sex, age, and body mass index, the 24 h arsenic excretion was on average low in Liege (91 nmol), Charleroi (155 nmol), Hechtel-Eksel (144 nmol), and Wezel (158 nmol), whereas the highest excretions were found in Lommel (570 nmol) and Pelt (373 nmol). During the PheeCad study, the mean 24 h arsenic excretion in the rural areas ranged from 81 to 111 nmol. This was lower than six years earlier and similar to the excretion in the control town (108 nmol). Longitudinal studies in 529 people Living in the rural areas confirmed that their 24 h arsenic excretion had decreased (P