Mild chronic kidney disease and its relation to functional disability in Korean elderly population
Mild chronic kidney disease and its relation to functional disability in Korean elderly population
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DOI：
10.1007/s11255-020-02559-y
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发表时间：
2020-07-13
影响因子：
2
通讯作者：
Lee, Dong-Young
中科院分区：
文献类型：
--
作者：
Park, Sung Keun;Kim, Won Joong;Lee, Dong-Young
研究表明，慢性肾脏疾病（CKD）与日常活动和移动功能困难的风险增加显著相关。然而，亚洲人CKD与功能障碍之间的关联数据较少。方法利用韩国国家健康与营养调查III的数据，我们调查了882名65岁以上的受试者CKD与功能障碍的关系。在日常生活活动（ADL）、工具性ADL （IADL）以及视觉、听觉和行走功能方面确定残疾。根据CKD分期评估残疾患病率，并采用多因素logistic回归分析计算CKD 3a期在ADL、IADL、视觉、听力和行走功能方面残疾的调整比值比（ORs）和95%置信区间（CI）[调整ORs (95% CI)]。结果CKD 3-4期患者的ADL、IADL、视觉、听力和行走功能残疾率均高于非CKD患者。即使在调整糖尿病、高血压、教育程度、收入、婚姻状况、年龄和性别后，CKD 3a期与ADL异常[1.63(1.04-2.54)]和视力障碍[1.39(1.01-1.93)]有显著相关性。结论轻度CKD的存在与日常活动和多种功能障碍有显著相关性。
Purpose Studies have demonstrated that chronic kidney disease (CKD) is significantly associated with the increased risk of functional difficulty in daily activity and mobility. However, data are less available for association between CKD and functional disability in Asians. Methods Using a data from Korea National Health and Nutrition Examination Survey III, we investigated the association of CKD with functional disability in 882 subjects over the age of 65. Disability was identified in activity of daily living (ADL), instrumental ADL (IADL), and visual, hearing, and walking function. The prevalence of disability was evaluated according to the stage of CKD, and multivariate logistic regression analysis was used to calculate the adjusted odds ratios (ORs) and 95% confidence interval (CI) [adjusted ORs (95% CI)] of CKD stage 3a for disability in ADL, IADL, visual, hearing, and walking function. Results Individuals with CKD stage 3-4 had the higher prevalence of disability ADL, IADL, visual, hearing, and walking function than individuals without CKD. CKD stage 3a was significantly associated with abnormal ADL [1.63 (1.04-2.54)] and visual impairment [1.39 (1.01-1.93)] even after adjusting for DM, hypertension, education, income, marital status, age, and sex. Conclusion The presence of mild CKD was significantly associated with disability in daily activity and multiple function.