The I′ potential of the human auditory brainstem response to paired click stimuli
The I′ potential of the human auditory brainstem response to paired click stimuli
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DOI：
10.1080/010503901750069572
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Moore, EJ
中科院分区：
文献类型：
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作者：
Davis-Gunter, MJ;Löwenheim, H;Moore, EJ
当用适当的刺激刺激时，Corti器官的毛细胞去极化，导致一种神经递质物质的释放，这刺激了传入的VIIIth神经树突。可以合理地假设，听神经树突产生的兴奋性突触后电位(EPSP)进而引发复合动作电位(CAP)。EPSP被认为是CAP的产生电位，在听性脑干反应(ABR)中可能被记录为I‘电位。确定I‘的解剖来源可能会提高ABR技术在毛细胞/树突/听神经评估中的敏感性。我是感觉起源还是神经起源是模棱两可的，因此我没有被很好地理解。为了研究这一困境，使用标准和配对的点击刺激，并使用减法产生派生的ABR，记录了受试者的ABR。两个早期的峰值，标记为I度和I‘，出现在派生的ABR中的I波之前。假设I度峰和I‘峰分别代表耳蜗神经和第VIIIth神经树突产生的总和电位和产生器电位。
When stimulated with an appropriate stimulus, the hair cells of the organ of Corti depolarize, causing the release of a neurotransmitter substance, which excites afferent VIIIth nerve dendrites. It is reasonable to hypothesize that excitatory postsynaptic potentials (EPSPs) generated by the dendrites of the auditory nerve in turn initiate a compound action potential (CAP). The EPSP is thought to be the generator potential for the CAP, and may be recorded in auditory brainstem responses (ABRs) as the I ' potential. Determining the anatomical origin of I ' may enhance the sensitivity of the ABR technique in hair cell/dendrite/auditory nerve evaluations. Whether I ' is of sensory or of neural origin is equivocal, and therefore I ' is not well understood. To investigate this dilemma, ABRs were recorded from human subjects using standard and paired-click stimuli, and using subtraction methods to generate a derived ABR. Two early peaks, designated as I degrees and I ', occurred before wave I in the derived ABR. It was hypothesized that peaks I degrees and I ' represent the summating potential and the generator potential, generated by the cochlea and VIIIth nerve dendrites, respectively.