TRIB1 rs17321515 gene polymorphism increases the risk of coronary heart disease in general population and non-alcoholic fatty liver disease patients in Chinese Han population
TRIB1 rs17321515 gene polymorphism increases the risk of coronary heart disease in general population and non-alcoholic fatty liver disease patients in Chinese Han population
复制标题
TRIB1 rs17321515基因多态性增加一般人群冠心病和中国汉族人群非酒精性脂肪肝患者的患病风险
DOI：
10.1186/s12944-019-1108-2
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发表时间：
2019-08-31
影响因子：
4.5
通讯作者：
Xin, Yong-Ning
中科院分区：
文献类型：
--
作者：
Liu, Qun;Liu, Shou-Sheng;Xin, Yong-Ning
研究背景现有证据表明TRIB 1 rs 17321515基因多态性与NAFLD和CHD的发病风险密切相关。CHD是NAFLD的主要并发症之一，TRIB 1 rs 17321515基因多态性是否影响普通人群和中国汉族人群NAFLD患者CHD的发病风险尚不清楚。本研究旨在探讨TRIB 1 rs 17321515基因多态性与中国汉族人群冠心病和非酒精性脂肪肝的关系，方法采用聚合酶链反应（PCR）技术对175例健康对照者TRIB 1 rs 17321515基因多态性进行分型，并与正常对照组比较。CHD组155例，NAFLD组146例，NAFLD+CHD组156例。采用生化方法测定血脂谱。结果TRIB 1 rs 17321515 AA+GA基因型是普通人群冠心病的显著危险因素非酒精性脂肪性肝病组OR = 1.760; 95% CI：1.071 - 2.891;P= 0.026。校正年龄、性别和体重指数后，普通人群（OR = 1.857，95%CI：1.116-3.089，P= 0.017）和NAFLD患者（OR = 1.723，95%CI：1.033-2.873，P= 0.037）患冠心病的危险性仍有显著性差异。结论TRIB 1 rs 17321515 AA+GA基因型与中国汉族人群CHD的发生及NAFLD的发生相关。rs 17321515 A等位基因增加纳入受试者的血脂谱。
BackgroundPresent evidences suggested thatTRIB1rs17321515 polymorphism was tightly associated with the increased risk of NAFLD and CHD. CHD is one of the main complications of NAFLD, whetherTRIB1rs17321515 polymorphism could affect the risk of CHD in general population and NAFLD patients in Chinese Han population was remain unknown. The present study was designed to investigate the association betweenTRIB1rs17321515 polymorphism and the risk of CHD in general population and NAFLD patients in Chinese Han population, and investigate the effect ofTRIB1rs17321515 polymorphism on serum lipid levels.Patients and methodsTRIB1rs17321515 gene polymorphism was genotyped using the polymerase chain reaction (PCR) in healthy controls (n= 175), CHD patients (n= 155), NAFLD patients (n= 146), and NAFLD+CHD patients (n= 156). Serum lipid profiles were determined using biochemical methods. Statistical analyses were performed using SPSS 24.0 statistical software.ResultsTheTRIB1rs17321515 AA+GA genotypes were the significant risk factors for the CHD in general population (OR = 1.788; 95% CI: 1.104–2.897;P= 0.018) and in the NAFLD patients (OR = 1.760; 95% CI: 1.071–2.891;P= 0.026). After adjusted for age, gender, and body mass index, the risk for CHD in general population (OR = 1.857; 95% CI: 1.116–3.089;P= 0.017) and NAFLD patients was still significant (OR = 1.723; 95% CI: 1.033–2.873;P= 0.037). In addition,TRIB1rs17321515 A carriers possess the higher lipid profiles in the included subjects.ConclusionsTRIB1rs17321515 AA+GA genotypes were significant associated with the risk of CHD in general population and in NAFLD patients in Chinese Han population. The rs17321515 A allele increases the serum lipid profiles in included subjects.