Cortical Spectral Activity and Connectivity during Active and Viewed Arm and Leg Movement.
Cortical Spectral Activity and Connectivity during Active and Viewed Arm and Leg Movement.
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DOI：
10.3389/fnins.2016.00091
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发表时间：
2016
影响因子：
4.3
通讯作者：
Ferris DP
中科院分区：
文献类型：
--
作者：
Kline JE;Huang HJ;Snyder KL;Ferris DP
主动和观察到的肢体运动会激活许多相似的神经通路，然而，迄今为止，大多数比较研究都集中在受试者进行手和脚的小而离散的运动。本研究的目的是确定高密度脑电图 (EEG) 是否可以检测人类主动和观察有节奏的手臂和腿部运动期间皮质活动和连接性的差异。我们的主要假设是，由于神经募集的相似性，与主动肢体运动相比，我们在观察肢体运动期间会检测到相似但较弱的电皮层光谱波动和有效连接波动。第二个假设是，与腿部运动相比，我们会记录手臂运动更强的皮质光谱波动，因为有节奏的手臂运动比有节奏的腿部运动更依赖于脊柱上的控制。我们记录了 10 名年轻健康受试者在卧式踏步机上锻炼时的脑电图数据：(1) 双臂和双腿，(2) 仅双腿，(3) 仅双臂。受试者还观看了自己或其他人进行相同练习的视频回放。我们对数据进行了独立成分分析、偶极子拟合、谱分析和有效连通性分析。包括前运动皮层和辅助运动皮层、前扣带皮层、后扣带皮层和顶叶皮层的皮层区域在有节奏的肢体运动期间表现出显着的光谱波动。手臂运动条件下的这些波动往往比仅腿部运动条件下的波动更大，这表明人类有节奏的手臂运动比有节奏的腿部运动受到更强的皮质控制。在观察条件下，我们没有在这些区域中发现一致的光谱波动，但在主动和观察的有节奏的肢体运动期间，有效连接性在运动频率的谐波处发生波动。右前运动皮层和辅助运动皮层驱动网络。这些结果表明，在主动和观察到的人类有节奏的肢体运动期间，类似互连的神经网络正在运行。
Active and viewed limb movement activate many similar neural pathways, however, to date most comparison studies have focused on subjects making small, discrete movements of the hands and feet. The purpose of this study was to determine if high-density electroencephalography (EEG) could detect differences in cortical activity and connectivity during active and viewed rhythmic arm and leg movements in humans. Our primary hypothesis was that we would detect similar but weaker electrocortical spectral fluctuations and effective connectivity fluctuations during viewed limb exercise compared to active limb exercise due to the similarities in neural recruitment. A secondary hypothesis was that we would record stronger cortical spectral fluctuations for arm exercise compared to leg exercise, because rhythmic arm exercise would be more dependent on supraspinal control than rhythmic leg exercise. We recorded EEG data while ten young healthy subjects exercised on a recumbent stepper with: (1) both arms and legs, (2) just legs, and (3) just arms. Subjects also viewed video playback of themselves or another individual performing the same exercises. We performed independent component analysis, dipole fitting, spectral analysis, and effective connectivity analysis on the data. Cortical areas comprising the premotor and supplementary motor cortex, the anterior cingulate, the posterior cingulate, and the parietal cortex exhibited significant spectral fluctuations during rhythmic limb exercise. These fluctuations tended to be greater for the arms exercise conditions than for the legs only exercise condition, which suggests that human rhythmic arm movements are under stronger cortical control than rhythmic leg movements. We did not find consistent spectral fluctuations in these areas during the viewed conditions, but effective connectivity fluctuated at harmonics of the exercise frequency during both active and viewed rhythmic limb exercise. The right premotor and supplementary motor cortex drove the network. These results suggest that a similarly interconnected neural network is in operation during active and viewed human rhythmic limb movement.