THE INFLUENCE OF MEDICAL CONDITIONS ASSOCIATED WITH HORMONES ON THE RISK OF BREAST-CANCER
THE INFLUENCE OF MEDICAL CONDITIONS ASSOCIATED WITH HORMONES ON THE RISK OF BREAST-CANCER
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DOI：
10.1093/ije/22.6.1000
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发表时间：
1993-12-01
影响因子：
7.7
通讯作者：
PASTERNACK, BS
中科院分区：
文献类型：
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作者：
MOSESON, M;KOENIG, KL;PASTERNACK, BS
在一项对参加筛查中心的妇女进行的乳腺癌病例对照研究中，调查了与激素异常有关的医疗状况。通过电话访谈获得了关于医生诊断的疾病的信息，如甲状腺或肝脏疾病、糖尿病和高血压，以及多毛症、痤疮、乳漏，以及生殖、月经和妇科因素。报告了354例病例和747例对照的结果。有生育问题但从未成功怀孕的妇女患乳腺癌的风险显著增加（校正优势比[OR] = 3.5； 95%可信区间[CI]: 1.1-10.9）。患癌风险升高还与体毛过多（OR = 1.5; 95% CI: 1.0-2.3），或体毛过多加上持续的成人痤疮（OR = 6.8; 95% CI: 1.7-27.1）有关。复发性闭经（OR = 3.5; 95% CI: 1.1-11.5）和治疗过的甲状腺功能亢进（OR = 2.2; 95% CI: 1.1-4.4）与风险显著相关。子宫内膜增生的风险无显著升高（OR = 1.8; 95% CI: 0.8-4.0）。在绝经前妇女中，有乳漏史与乳腺癌风险之间存在关联（OR = 2.0; 95% CI: 0.8-4.9）。未发现与其他医学或妇科因素有关。由于多重比较的问题，不能排除这些发现中的一些是偶然的可能性。
Medical conditions related to hormonal abnormalities were investigated in a case-control study of breast cancer among women who attended a screening centre. Information was obtained by telephone interview regarding physician-diagnosed medical conditions such as thyroid or liver diseases, diabetes, and hypertension, as well as hirsutism, acne, galactorrhoea, and reproductive, menstrual, and gynaecological factors. Results are presented for 354 cases and 747 controls. Women with fertility problems who never succeeded in becoming pregnant were at significantly increased breast cancer risk (adjusted odds ratio [OR] = 3.5; 95% confidence interval [CI] : 1.1-10.9). An elevated cancer risk was also associated with having excess body hair (OR = 1.5; 95% CI : 1.0-2.3), or having excess body hair in addition to persistent adult acne (OR = 6.8; 95% CI : 1.7-27.1). Recurrent amenorrhoea (OR = 3.5; 95% CI : 1.1-11.5), and a treated hyperthyroid condition (OR = 2.2; 95% CI: 1.1-4.4) were significantly associated with risk. A non-significant elevation of risk was present for endometrial hyperplasia (OR = 1.8; 95% CI : 0.8-4.0). There was a suggestion of an association between a history of galactorrhoea and breast cancer risk (OR = 2.0; 95% CI : 0.8-4.9) among premenopausal women. No associations were found with other medical or gynaecological factors. The possibility that some of these findings are due to chance cannot be excluded because of the problem of multiple comparisons.