KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients.
KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients.
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DOI：
10.1038/s41598-021-04416-z
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发表时间：
2022-01-11
影响因子：
4.6
通讯作者：
Douglas VC
中科院分区：
文献类型：
--
作者：
Terrelonge M;LaHue SC;Tang C;Movsesyan I;Pullinger CR;Dubal DB;Leung J;Douglas VC
尽管认知障碍和谵妄之间存在关联，但人们对赋予认知弹性的基因差异是否也赋予对谵妄的抵抗力知之甚少。研究与术后谵妄患者相比，无术后谵妄的老年人是否更有可能在已知与认知或谵妄相关的FKBP5、KIBRA、KLOTHO、MTNR1B和SIRT1基因中具有特异性单核苷酸多态性（snp）。这项前瞻性巢式匹配探索性病例对照研究包括94名接受骨科手术并筛查术后谵妄的老年人。47名受试者有偶发性谵妄，47名年龄匹配的对照组没有谵妄。主要研究结果是5个snp的基因型频率。与谵妄患者相比，非谵妄患者KIBRA SNP rs17070145 CT/TT的调整几率更高[vs. CC；校正优势比（aOR） 2.80, 95%可信区间（CI） 1.03, 7.54；p = 0.04]和MTNR1B SNP rs10830963 CG/GG （vs. CC; aOR 4.14, 95% CI 1.36, 12.59; p = 0.01）。FKBP5 SNP rs1360780 CT/TT（与CC相比）显示不发生谵妄的调整几率增加（aOR 2.51, 95% CI 1.00, 7.34; p = 0.05）。我们的研究结果强调了KIBRA、MTNR1B和FKBP5在理解谵妄、认知和睡眠之间复杂关系方面的相关性，这值得在更大、更多样化的人群中进一步研究。
Despite the association between cognitive impairment and delirium, little is known about whether genetic differences that confer cognitive resilience also confer resistance to delirium. To investigate whether older adults without postoperative delirium, compared with those with postoperative delirium, are more likely to have specific single nucleotide polymorphisms (SNPs) in the FKBP5, KIBRA, KLOTHO, MTNR1B, and SIRT1 genes known to be associated with cognition or delirium. This prospective nested matched exploratory case–control study included 94 older adults who underwent orthopedic surgery and screened for postoperative delirium. Forty-seven subjects had incident delirium, and 47 age-matched controls were not delirious. The primary study outcome was genotype frequency for the five SNPs. Compared with participants with delirium, those without delirium had higher adjusted odds of KIBRA SNP rs17070145 CT/TT [vs. CC; adjusted odds ratio (aOR) 2.80, 95% confidence interval (CI) 1.03, 7.54; p = 0.04] and MTNR1B SNP rs10830963 CG/GG (vs. CC; aOR 4.14, 95% CI 1.36, 12.59; p = 0.01). FKBP5 SNP rs1360780 CT/TT (vs. CC) demonstrated borderline increased adjusted odds of not developing delirium (aOR 2.51, 95% CI 1.00, 7.34; p = 0.05). Our results highlight the relevance of KIBRA, MTNR1B, and FKBP5 in understanding the complex relationship between delirium, cognition, and sleep, which warrant further study in larger, more diverse populations.
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DOI：
10.1093/gerona/glw149
发表时间：
2016-11
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Newman JC;Milman S;Hashmi SK;Austad SN;Kirkland JL;Halter JB;Barzilai N
通讯作者：
Barzilai N
影响因子：
39
作者：
Hshieh, Tammy T.;Yue, Jirong;Oh, Esther;Puelle, Margaret;Dowal, Sarah;Travison, Thomas;Inouye, Sharon K.
通讯作者：
Inouye, Sharon K.
影响因子：
168.9
作者：
Inouye, Sharon K.;Westendorp, Rudi G. J.;Saczynski, Jane S.
通讯作者：
Saczynski, Jane S.
影响因子：
2.6
作者：
LaHue, Sara C;Maselli, Judy;Rogers, Stephanie;Casatta, Julie;Chao, Jessica;Croci, Rhiannon;Gonzales, Ralph;Holt, Brian;Josephson, S Andrew;Lama, Sudha;Lau, Catherine;McCulloch, Charles;Newman, John C;Terrelonge, Mark;Yeager, Jan;Douglas, Vanja C
通讯作者：
Douglas, Vanja C
影响因子：
4.6
作者：
Porter T;Burnham SC;Doré V;Savage G;Bourgeat P;Begemann K;Milicic L;Ames D;Bush AI;Maruff P;Masters CL;Rowe CC;Rainey-Smith S;Martins RN;Groth D;Verdile G;Villemagne VL;Laws SM
通讯作者：
Laws SM