Selective sweep in the Flotillin-2 region of European Drosophila melanogaster.
Selective sweep in the Flotillin-2 region of European Drosophila melanogaster.
复制标题
DOI：
10.1371/journal.pone.0056629
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Laurent S
中科院分区：
文献类型：
--
作者：
Werzner A;Pavlidis P;Ometto L;Stephan W;Laurent S
定位受近期正选择影响的基因是进化生物学的一个主要目标。在模式生物黑腹果蝇中，近年来进行了许多尝试，通过进行所谓的基因组选择扫描来识别这些基因。这些分析包括在个体样本的基因组中对大量遗传标记进行分型，然后识别那些包含遗传变异模式的位点，这些模式与选择性扫描产生的模式兼容。在这项研究中，我们深入分析了位于D. melanogaster X染色体上的一个基因组区域，该区域在之前的基因组选择扫描中被确定为近期正选择的潜在目标。为此，我们对flotilin -2基因（flo2）周围的20万个碱基进行了重新测序，并对新数据集中观察到的等位基因频率和连锁不平衡进行了详细分析。这项分析的结果揭示了8个遗传新特征，这些新特征是温带黑腹龙特有的，可能是在大约1.6万年前该物种从其祖先的撒哈拉以南栖息地向外扩张的过程中出现的。
Localizing genes that are subject to recent positive selection is a major goal of evolutionary biology. In the model organism Drosophila melanogaster many attempts have been made in recent years to identify such genes by conducting so-called genome scans of selection. These analyses consisted in typing a large number of genetic markers along the genomes of a sample of individuals and then identifying those loci that harbor patterns of genetic variation, which are compatible with the ones generated by a selective sweep. In this study we conduct an in-depth analysis of a genomic region located on the X chromosome of D. melanogaster that was identified as a potential target of recent positive selection by a previous genome scan of selection. To this end we re-sequenced 20 kilobases around the Flotillin-2 gene (Flo-2) and conducted a detailed analysis of the allele frequencies and linkage disequilibria observed in this new dataset. The results of this analysis reveal eight genetic novelties that are specific to temperate populations of D. melanogaster and that may have arisen during the expansion of the species outside its ancestral sub-Saharan habitat since about 16,000 years ago.
登录
查看更多内容
影响因子：
11.4
作者：
Katanaev, Vladimir L.;Solis, Gonzalo P.;Hausmann, George;Buestorf, Silke;Katanayeva, Natalya;Schrock, Yvonne;Stuermer, Claudia A. O.;Basler, Konrad
通讯作者：
Basler, Konrad
影响因子：
10.5
作者：
CALLIS, J;FROMM, M;WALBOT, V
通讯作者：
WALBOT, V
影响因子：
3.3
作者：
Hutter, Stephan;Li, Haipeng;Stephan, Wolfgang
通讯作者：
Stephan, Wolfgang
影响因子：
3.3
作者：
Kim, Y;Nielsen, R
通讯作者：
Nielsen, R
影响因子：
3.3
作者：
Beisswanger, S;Stephan, W;De Lorenzo, D
通讯作者：
De Lorenzo, D