The creatine kinase profile of a maintenance hemodialysis population: a possible marker of uremic myopathy.
The creatine kinase profile of a maintenance hemodialysis population: a possible marker of uremic myopathy.
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维持性血液透析人群的肌酸激酶谱：尿毒症肌病的可能标志物。
作者：
I. Cohen;J. Griffiths;R. Stone;T. Leech
我们调查了100例定期血液透析患者的血清肌酸激酶（CK）和同工酶活性（MM，MB，BB），以确定在这些患者中的一部分，在没有临床事件的情况下偶然注意到持续升高的CK的意义，以解释这一发现。19名患者（19%）在研究期间持续CK升高，骨骼肌同工酶（MM）占主导地位。BB均在正常范围内，MB仅2例超过总CK的3.0%。透析前血尿素氮均值显著高于CK正常组（P < 0.02），每千克干体重血清肌酸均值显著高于CK正常组（P < 0.05）。血清碳酸氢盐测定腓神经传导速度各组间无显著性差异。CK活性也与透析前血尿素氮值显著相关（r = 0.52，P <0.001）。先前在尿毒症中注意到的氮代谢紊乱使我们得出结论，过量的骨骼肌CK可能与某些尿毒症患者中注意到的肌肉萎缩有关。
We surveyed the sera of 100 regularly hemodialyzed patients for creatine kinase (CK) and isoenzyme activity (MM, MB, BB) in order to determine the meaning of persistently elevated CK fortuitously noted in a porportion of these patients in the absence of clinical events to account for this finding. Nineteen patients (19 percent) had sustained CK elevation over the period of investigation with the skeletal muscle isoenzyme (MM) predominating. BB was within the normal range in these patients and MB exceeded 3.0% of total CK in only 2 patients. The pre-dialysis blood urea nitrogen mean for ths group was significantly higher (P < 0.02) as was the serum creatine per kilogram of dry body weight (P < 0.05) than for the group with normal CK totals. There was no significant difference in peroneal nerve conduction velocity of serum bicarbonate between these groups. CK activity also correlated significantly with predialysis blood urea nitrogen values (r = 0.52, P < .001). The deranged nitrogen metabolism previously noted in uremia leads us to conclude that the excess skeletal muscle CK may be related to the muscle wasting noted in some uremic patients.