Three-dimensional high-resolution simultaneous quantitative mapping of the whole brain with 3D-QALAS: An accuracy and repeatability study
Three-dimensional high-resolution simultaneous quantitative mapping of the whole brain with 3D-QALAS: An accuracy and repeatability study
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DOI：
10.1016/j.mri.2019.08.031
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发表时间：
2019-11-01
影响因子：
2.5
通讯作者：
Aoki, Shigeki
中科院分区：
文献类型：
--
作者：
Fujita, Shohei;Hagiwara, Akifumi;Aoki, Shigeki
背景：以前利用磁共振成像对脑组织属性进行量化的方法主要基于二维采集，因此与三维(3D)采集相比，在切片方向上的分辨率相对较低。目的：评价3D-QALAS松弛测量参数的偏差、线性度和日常可重复性。材料和方法：在1.5T扫描仪上对3D-QALAS序列进行扫描-再扫描测试。平均年龄23.2+/-3.6岁)。使用简单线性回归分析、Bland-Altman图和对象内变异系数(CV)来评估3D-QALAS序列衍生参数的可靠性。结果：在体模研究中，3D-QALAS测量的T1、T2和PD与参考值具有很好的线性关系(R2分别为0.998、0.998和0.960)，重复性好(T1、T2和PD的平均变异系数分别为1.2%、2.8%和2.9%)。3D-QALAS获得的活体脑区的T1、T2、PD和MVF值在受试者内高度一致，对象内的平均变异系数分别为0.5%、0.5%、0.4%和1.6%。结论：3D-QALAS能够在临床相关的动态范围内以高空间分辨率可靠地测量全脑的T1、T2、PD和MVF值。
Background: Previous methods for the quantification of brain tissue properties by magnetic resonance imaging were mainly based on two-dimensional acquisitions and were thus limited to a relatively low resolution in the slice direction compared to three-dimensional (3D) acquisitions. The 3D-quantification using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse (3D-QALAS) sequence may allow for simultaneous acquisition of relaxometry parameters in high spatial resolution.Purpose: To evaluate bias, linearity, and day-to-day repeatability of relaxometry parameters, as well as tissue fraction maps, acquired with 3D-QALAS.Materials and methods: Scan-rescan test of the 3D-QALAS sequence was performed on a 1.5-T scanner with the International Society for Magnetic Resonance in Medicine/National institute of Standards and Technology system phantom and 10 healthy volunteers (7 male, 3 female; mean age, 23.2 +/- 3.6 years). Simple linear regression analysis, Bland-Altman plots, and intrasubject coefficients of variation (CV) were used to assess the reliability of 3D-QALAS sequence-derived parameters. The T1, T2, proton density (PD), and myelin volume fraction (MVF) of in vivo brain regions were compared with values obtained using the multidynamic multi-echo sequence.Results: In the phantom study, the T1, T2, and PD values measured by 3D-QALAS showed strong linearity with the reference values (R-2 = 0.998, 0.998, and 0.960 for T1, T2, and PD, respectively) and high repeatability (mean CV of 1.2%, 2.8%, and 2.9% for T1, T2, and PD, respectively). The T1, T2, PD, and MVF values of in vivo brain regions obtained with 3D-QALAS were highly consistent within subjects, with mean intrasubject CVs of 0.5%, 0.5%, 0.4%, and 1.6% for the T1, T2, PD, and MVF values, respectively.Conclusion: 3D-QALAS enables reliable measurement of T1, T2, PD, and MVF values of the whole brain in high spatial resolution across a clinically-relevant dynamic range.